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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/17128

Title: Maternal venous hemodynamics in gestational hypertension and preeclampsia
Authors: Gyselaers, Wilfried
Tomsin, Kathleen
Staelens, Anneleen
Mesens, Tinne
Oben, Jolien
Molenberghs, Geert
Issue Date: 2014
Abstract: Background: To evaluate characteristics of venous hemodynamics, together with cardiac and arterial function, in uncomplicated pregnancies (UP), non-proteinuric gestational hypertension (GH) and preeclampsia (PE). Methods: In this observational cross-sectional study, venous hemodynamics was assessed using a standardised protocol for combined electrocardiogram (ECG)-Doppler ultrasonography, together with a non-invasive standardised cardiovascular assessment using impedance cardiography (ICG) in 13 women with UP, 21 with GH, 34 with late onset PE >= 34 w (LPE) and 22 with early onset PE < 34 w (EPE). ECG-Doppler parameters were impedance index at the level of hepatic veins (HVI) and renal interlobar veins (RIVI) together with venous pulse transit times (VPTT), as well as resistive and pulsatility index, and arterial pulse transit time (APTT) at the level of uterine arcuate arteries. ICG parameters were aortic flow velocity index (VI), acceleration index (ACI) and thoracic fluid content. Mann Whitney U-test, Kruskall-Wallis test and linear regression analysis with heteroskedastic variance was used for statistical analysis. Results: RIVI in both kidneys was > 15% higher (P <= .010) in LPE and EPE, as compared to GH and UP. Next to this, >30% lower values for VI and ACI (P <= .029), and > 15% lower values for APTT (P <= .012) were found in GH, LPE and EPE, as compared to GH. Conclusion: In comparison to UP, similar abnormalities of central arterial function and APTT were found in GH, EPE and LPE. Proteinuria of LPE and EPE was associated with increased RIVI, this was not observed in GH.
Notes: Gyselaers, W (reprint author), Ziekenhuis Oost, Dept Obstet & Gynaecol, Limburg Schiepse Bos 6, B-3600 Genk, Belgium. wilfried.gyselaers@zol.be
URI: http://hdl.handle.net/1942/17128
DOI: 10.1186/1471-2393-14-212
ISI #: 000338742500001
ISSN: 1471-2393
Category: A1
Type: Journal Contribution
Validation: ecoom, 2015
Appears in Collections: Research publications

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