Document Server@UHasselt >
Research >
Research publications >

Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/17114

Title: Prevention of central line-associated bloodstream infections through quality improvement interventions: a systematic review and meta-analysis
Authors: Blot, Koen
BERGS, Jochen
Vogelaers, Dirk
Blot, Stijn
VANDIJCK, Dominique
Issue Date: 2014
Citation: CLINICAL INFECTIOUS DISEASES, 59 (1), p. 96-105
Abstract: This systematic review and meta-analysis examines the impact of quality improvement interventions on central line–associated bloodstream infections in adult intensive care units. Studies were identified through Medline and manual searches (1995–June 2012). Random-effects meta-analysis obtained pooled odds ratios (ORs) and 95% confidence intervals (CIs). Meta-regression assessed the impact of bundle/checklist interventions and high baseline rates on intervention effect. Forty-one before–after studies identified an infection rate decrease (OR, 0.39 [95% CI, .33–.46]; P < .001). This effect was more pronounced for trials implementing a bundle or checklist approach (P = .03). Furthermore, meta-analysis of 6 interrupted time series studies revealed an infection rate reduction 3 months postintervention (OR, 0.30 [95% CI, .10–.88]; P = .03). There was no difference in infection rates between studies with low or high baseline rates (P = .18). These results suggest that quality improvement interventions contribute to the prevention of central line–associated bloodstream infections. Implementation of care bundles and checklists appears to yield stronger risk reductions.
URI: http://hdl.handle.net/1942/17114
DOI: 10.1093/cid/ciu239
ISI #: 000339665000019
ISSN: 1058-4838
Category: A1
Type: Journal Contribution
Validation: ecoom, 2015
Appears in Collections: Research publications

Files in This Item:

Description SizeFormat
N/A591.64 kBAdobe PDF

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.