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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/17079

Title: Impact of differently modified nanocrystalline diamond on the growth of neuroblastoma cells.
Authors: Vaitkuviene, A.
NOBEN, Jean-Paul
SANEN, Kathleen
Ratautaite, V.
Kaseta, V.
Biziuleviciene, G.
Ramanaviciene, A.
Ramanavicius, A.
Issue Date: 2015
Citation: New Biotechnology, 32 (1), p. 7-12
Abstract: The aim of this study was to assess the impact of nanocrystalline diamond (NCD) thin coatings on neural cell adhesion and proliferation. NCD was fabricated on fused silica substrates by microwave plasma chemical vapor deposition (MPCVD) method. Different surface terminations were performed through exposure to reactive hydrogen and by UV induced oxidation during ozone treatment. Boron doped NCD coatings were also prepared and investigated. NCD surface wettability was determined by contact angle measurement. To assess biocompatibility of the NCD coatings, the neuroblastoma SH-SY5Y cell line was used. Cells were plated directly onto diamond surfaces and cultured in medium with or without fetal bovine serum (FBS), in order to evaluate the ability of cells to adhere and to proliferate. The obtained results showed that these cells adhered and proliferated better on NCD surfaces than on the bare fused silica. The cell proliferation on NCD in medium with and without FBS after 48 h from plating was on average, respectively, 20 and 58% higher than that on fused silica, irrespective of NCD surface modification. Our results showed that the hydrogenated, oxygenated and boron-doped NCD coatings can be used for biomedical purposes, especially where good optical transparency is required.
Notes: Ramanavicius, A (reprint author), Vilnius State Univ, Fac Chem, Dept Phys Chem, Naugarduko 24, LT-03225 Vilnius, Lithuania. Arunas.Ramanavicius@chf.vu.lt
URI: http://hdl.handle.net/1942/17079
DOI: 10.1016/j.nbt.2014.06.008
ISI #: 000347507800002
ISSN: 1871-6784
Category: A1
Type: Journal Contribution
Validation: ecoom, 2016
Appears in Collections: Research publications

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