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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/16991

Title: Perinatal Exposure to Purity-Controlled Polychlorinated Biphenyl 52, 138, or 180 Alters Toxicogenomic Profiles in Peripheral Blood of Rats after 4 Months
Authors: De Boever, Patrick
Wens, Britt
Boix, Jordi
Felipo, Vicente
Schoeters, Greet
Issue Date: 2013
Citation: CHEMICAL RESEARCH IN TOXICOLOGY, 26 (8), p. 1159-1167
Abstract: It is known from controlled animal experiments and human epidemiologic studies that early life exposure to mixtures of polychlorinated biphenyls (PCBs) is a risk factor for developmental neurotoxicity. The importance of non-dioxin-like PCBs in the context of the observed effect is uncertain because of the blending with the more potent dioxin-like PCBs. Previously, a controlled rat perinatal exposure study with individual, purity-controlled, non-dioxin-like congeners (PCB52, PCB138, or PCB180) was set up. Impaired motor coordination, motor activity, and learning has been reported for the offspring at an age of approximately 4 months. Here, we report on the gene expression responses that have been observed in the blood of the same animals. ANOVA analysis called 1412 genes differentially expressed 4 months after the PCB treatment was stopped. Subsequently, each PCB exposure condition was compared to the corresponding vehicle control using a fold change analysis. The gene lists contained between 82 and 348 differentially expressed genes. Expression patterns were complex with sets of differentially expressed genes being specific for a particular PCB exposure and other sets in common between several exposure conditions. Thirty-two genes were differentially expressed under all conditions. Bioinformatic overrepresentation analysis identified enriched biological terms such as lipid metabolism, molecular transport, small molecule biochemistry, and cell signaling and proliferation. Gene lists were particularly enriched for nervous system development and function ontology. In conclusion, we have documented for the first time differential gene expression in a well-controlled animal study that reported behavioral effects of purity-controlled individual non-dioxin-like PCBs.
Notes: [De Boever, Patrick; Wens, Britt; Schoeters, Greet] Flemish Inst Technol Res VITO, Unit Environm Risk & Hlth, B-2400 Mol, Belgium. [De Boever, Patrick] Hasselt Univ, Ctr Environm Sci, B-3590 Diepenbeek, Belgium. [Boix, Jordi; Felipo, Vicente] Ctr Invest Principe Felipe, Lab Neurobiol, Valencia 46012, Spain. [Schoeters, Greet] Univ Antwerp, Dept Biomed Sci, B-2610 Antwerp, Belgium. [Schoeters, Greet] Univ Southern Denmark, Dept Environm Med, DK-5100 Odense, Denmark.
URI: http://hdl.handle.net/1942/16991
DOI: 10.1021/tx300510v
ISI #: 000323460600004
ISSN: 0893-228X
Category: A1
Type: Journal Contribution
Validation: ecoom, 2014
Appears in Collections: Research publications

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