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|Title: ||Selective Identification of Macrophages and Cancer Cells Based on Thermal Transport through Surface-Imprinted Polymer Layers|
|Authors: ||Eersels, Kasper|
van Grinsven, Bart
Monroy, Kathia L. Jimenez
Bogie, Jeroen F. J.
Hendriks, Jerome J. A.
Cleij, Thomas J.
Daemen, Mat J. A. P.
De Ceuninck, Ward
|Issue Date: ||2013|
|Publisher: ||AMER CHEMICAL SOC|
|Citation: ||ACS APPLIED MATERIALS & INTERFACES, 5 (15), p. 7258-7267|
|Abstract: ||In this article, we describe a novel straightforward method for the specific identification of viable cells (macrophages and cancer cell lines MCF-7 and Jurkat) in a buffer solution. The detection of the various cell types is based on changes of the heat transfer resistance at the solid-liquid interface of a thermal sensor device induced by binding of the cells to a surface-imprinted polymer layer covering an aluminum chip. We observed that the binding of cells to the polymer layer results in a measurable increase of heat transfer resistance, meaning that the cells act as a thermally insulating layer. The detection limit was found to be on the order of 10(4) cells/mL, and mutual cross-selectivity effects between the cells and different types of imprints were carefully characterized. Finally, a rinsing method was applied, allowing for the specific detection of cancer cells with their respective imprints while the cross-selectivity toward peripheral blood mononuclear cells was negligible. The concept of the sensor platform is fast and low-cost while allowing also for repetitive measurements.|
|Notes: ||[Eersels, Kasper; van Grinsven, Bart; Ethirajan, Anitha; Monroy, Kathia L. Jimenez; Punniyakoti, Sathya; Cleij, Thomas J.; De Ceuninck, Ward; Wagner, Patrick] Hasselt Univ, Inst Mat Res IMO, B-3590 Diepenbeek, Belgium. [Timmermans, Silke; Bogie, Jeroen F. J.; Hendriks, Jerome J. A.; Somers, Veerle] Hasselt Univ, Inst Biomed Res BIOMED, B-3590 Diepenbeek, Belgium. [Vandenryt, Thijs] XIOS Univ Coll, Dept Appl Engn, B-3590 Diepenbeek, Belgium. [Cleij, Thomas J.] Maastricht Univ, Maastricht Sci Programme, NL-6200 MD Maastricht, Netherlands. [Daemen, Mat J. A. P.] Univ Amsterdam, Acad Med Ctr, NL-1105 AZ Amsterdam, Netherlands. [De Ceuninck, Ward; Wagner, Patrick] IMEC Vzw, IMOMEC Div, B-3590 Diepenbeek, Belgium.|
|ISI #: ||000323241100068|
|Type: ||Journal Contribution|
|Validation: ||ecoom, 2014|
|Appears in Collections: ||Research publications|
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