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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/16986

Title: Proteomic analysis of rat tibialis anterior muscles at different stages of experimental autoimmune myasthenia gravis
Authors: Gomez, Alejandro M.
Vanheel, Annelies
Losen, Mario
Molenaar, Peter C.
De Baets, Marc H.
Noben, Jean-Paul
Hellings, Niels
Martinez-Martinez, Pilar
Issue Date: 2013
Citation: JOURNAL OF NEUROIMMUNOLOGY, 261 (1-2), p. 141-145
Abstract: Myasthenia gravis (MG) is an autoimmune disease in which autoantibodies, most commonly directed against the acetylcholine receptor (AChR), impair neuromuscular transmission and cause muscle weakness. In this study, we utilized two-dimensional difference in-gel electrophoresis (2D-DIGE) to analyze the muscles proteomic profile at different stages of experimental autoimmune myasthenia gravis (EAMG). We identified twenty-two differentially expressed proteins, mainly related to metabolic and stress-response pathways. Interestingly, these identified proteins have also been associated with other contraction-impairing muscle pathologies (e.g. inclusion body myositis), suggesting a similar response of the muscle to such conditions. (C) 2013 Elsevier B.V. All rights reserved.
Notes: [Gomez, Alejandro M.; Losen, Mario; Molenaar, Peter C.; De Baets, Marc H.; Martinez-Martinez, Pilar] Maastricht Univ, Sch Mental Hlth & Neurosci, Div Neurosci, NL-6200 MD Maastricht, Netherlands. [Vanheel, Annelies; De Baets, Marc H.; Noben, Jean-Paul; Hellings, Niels] Hasselt Univ, Biomed Res Inst, B-3500 Hasselt, Belgium. [Vanheel, Annelies; De Baets, Marc H.; Noben, Jean-Paul; Hellings, Niels] Transnatl Univ Limburg, Sch Life Sci, B-3500 Hasselt, Belgium.
URI: http://hdl.handle.net/1942/16986
DOI: 10.1016/j.jneuroim.2013.05.008
ISI #: 000323459400020
ISSN: 0165-5728
Category: A1
Type: Journal Contribution
Validation: ecoom, 2014
Appears in Collections: Research publications

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