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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/16985

Title: Block of a subset of sodium channels exacerbates experimental autoimmune encephalomyelitis
Authors: Stevens, Marijke
Timmermans, Silke
Bottelbergs, Astrid
Hendriks, Jerome J. A.
Brone, Bert
Baes, Myriam
Tytgat, Jan
Issue Date: 2013
Citation: JOURNAL OF NEUROIMMUNOLOGY, 261 (1-2), p. 21-28
Abstract: Voltage-gated sodium channels (Na(v)s) are involved in several aspects of the pathogenesis of multiple sclerosis (MS). Within acute MS plaques, they are expressed along demyelinated axons. Studies in experimental autoimmune encephalomyelitis (EAE) demonstrated a neuroprotective effect of non-specific Na-v blockers. Further, block of specific Na(v)s involved in MS is suggested to have an advantage over non-specific blockers. We investigated the effects of the synthetic Midi peptide in EAE, as it potently and specifically blocks Na(v)1.2, Na(v)1.4 and Na(v)1.6. Administration of this Midi peptide worsens the clinical disease pattern and Na(v)1.2 and Na(v)1.6 expression levels were elevated in brain but not in spinal cord of Midi-treated mice, implicating that Nays play a complex role in the pathogenesis of EAE. (C) 2013 Elsevier B.V. All rights reserved.
Notes: [Stevens, Marijke; Tytgat, Jan] Katholieke Univ Leuven, Dept Pharmaceut Sci, Toxicol Lab, B-3000 Louvain, Belgium. [Timmermans, Silke; Hendriks, Jerome J. A.; Brone, Bert] Hasselt Univ, Biomed Res Inst, B-3590 Diepenbeek, Belgium. [Timmermans, Silke; Hendriks, Jerome J. A.; Brone, Bert] Transnat Univ Limburg, B-3590 Diepenbeek, Belgium. [Bottelbergs, Astrid; Baes, Myriam] Katholieke Univ Leuven, Dept Pharmaceut Sci, Lab Cell Metab, B-3000 Louvain, Belgium.
URI: http://hdl.handle.net/1942/16985
DOI: 10.1016/j.jneuroim.2013.04.012
ISI #: 000323459400003
ISSN: 0165-5728
Category: A1
Type: Journal Contribution
Validation: ecoom, 2014
Appears in Collections: Research publications

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