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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/16948

Title: Health effects in the Flemish population in relation to low levels of mercury exposure: From organ to transcriptome level
Authors: Croes, Kim
De Coster, Sam
De Galan, Sandra
Morrens, Bert
Loots, Ilse
Van de Mieroop, Els
Nelen, Vera
Sioen, Isabelle
Bruckers, Liesbeth
Nawrot, Tim
Colles, Ann
Den Hond, Elly
Schoeters, Greet
van Larebeke, Nicolas
Baeyens, Willy
Gao, Yue
Issue Date: 2014
Abstract: Due to possible health risks, quantification of mercury accumulation in humans was included in the Flemish biomonitoring programmes FLEHS I (2002-2006) and FLEHS II (2007-2011). The general objective of FLEHS I was to assess regional exposure levels in order to link possible differences in these internal exposure levels to different types of local environmental pressure. Therefore, Hg and MMHg (methylmercury) were only measured in pooled blood samples per region and per age class. In FLEHS II, mercury concentrations were measured in hair of each participant. About 200 adolescents and 250 mothers (reference group) and two times 200 adolescents (2 hotspots) were screened. The main objectives of the FLEHS II study were: (1) to determine reference levels of mercury in hair for Flanders; (2) to assess relations between mercury exposure and possible sources like fish consumption; (3) to assess dose-effect relations between mercury exposure and health effect markers. The results showed that mercury concentrations in the Flemish population were rather low compared to other studies. Mercury levels in the Flemish populations were strongly related to the age of the participants and consumption of fish. Significant negative associations were observed between mercury in hair and asthma, having received breast feeding as a newborn, age at menarche in girls, allergy for animals and free testosterone levels. Significant correlations were also observed between mercury in hair and genes JAK2, ARID4A, Hist1HA4L (boys) and HLAdrb5, PIAS2, MANN1B1, GIT and ABCA1 (girls). (C) 2013 Elsevier GmbH. All rights reserved.
Notes: [Croes, Kim; De Galan, Sandra; Baeyens, Willy; Gao, Yue] Free Univ Brussels VUB, Dept Analyt & Environm Chem ANCH, B-1050 Brussels, Belgium. [De Coster, Sam; van Larebeke, Nicolas] Ghent Univ Hosp, Study Ctr Carcinogenesis & Primly Prevent Canc, B-9000 Ghent, Belgium. [Morrens, Bert; Loots, Ilse] Univ Antwerp, Fac Polit & Social Sci, Dept Sociol, B-2000 Antwerp, Belgium. [Van de Mieroop, Els; Nelen, Vera] Prov Inst Hyg, B-2000 Antwerp, Belgium. [Sioen, Isabelle] Univ Ghent, Dept Publ Hlth, B-9000 Ghent, Belgium. [Sioen, Isabelle] Res Fdn Flanders, B-1000 Brussels, Belgium. [Bruckers, Liesbeth] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat, B-3500 Hasselt, Belgium. [Nawrot, Tim] Katholieke Univ Leuven, Sch Publ Hlth Occupat & Environm Med, B-3000 Louvain, Belgium. [Nawrot, Tim] Hasselt Univ, Ctr Environm Sci, B-3590 Diepenbeek, Belgium. [Colles, Ann; Den Hond, Elly; Schoeters, Greet] Flemish Inst Technol Res VITO, B-2400 Mol, Belgium.
URI: http://hdl.handle.net/1942/16948
DOI: 10.1016/j.ijheh.2013.06.004
ISI #: 000331595500014
ISSN: 1438-4639
Category: A1
Type: Journal Contribution
Validation: ecoom, 2015
Appears in Collections: Research publications

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