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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/16712

Title: Combined aerobic/inspiratory muscle training vs. aerobic training in patients with chronic heart failure
Authors: Adamopoulos, Stamatis
Schmid, Jean-Paul
Dendale, Paul
Poerschke, Daniel
Hansen, Dominique
Dritsas, Athanasios
Kouloubinis, Alexandros
Alders, Toon
Gkouziouta, Aggeliki
Reyckers, Ilse
Vartela, Vasiliki
Plessas, Nikos
Doulaptsis, Costas
Saner, Hugo
Laoutaris, Ioannis D.
Issue Date: 2014
Citation: EUROPEAN JOURNAL OF HEART FAILURE, 16 (5), p. 574-582
Abstract: Aims Vent-HeFT is a multicentre randomized trial designed to investigate the potential additive benefits of inspiratory muscle training (IMT) on aerobic training (AT) in patients with chronic heart failure (CHF). Methods and results Forty-three CHF patients with a mean age of 58 ± 12 years, peak oxygen consumption (peak VO2) 17.9 ± 5 mL/kg/min, and LVEF 29.5 ± 5% were randomized to an AT/IMT group (n = 21) or to an AT/SHAM group (n = 22) in a 12-week exercise programme. AT involved 45 min of ergometer training at 70–80% of maximum heart rate, three times a week for both groups. In the AT/IMT group, IMT was performed at 60% of sustained maximal inspiratory pressure (SPImax) while in the AT/SHAM group it was performed at 10% of SPImax, using a computer biofeedback trainer for 30 min, three times a week. At baseline and at 3 months, patients were evaluated for exercise capacity, lung function, inspiratory muscle strength (PImax) and work capacity (SPImax), quality of life (QoL), LVEF and LV diameter, dyspnoea, C-reactive protein (CRP), and NT-proBNP. IMT resulted in a significantly higher benefit in SPImax (P = 0.02), QoL (P = 0.002), dyspnoea (P = 0.004), CRP (P = 0.03), and NT-proBNP (P = 0.004). In both AT/IMT and AT/SHAM groups PImax (P < 0.001, P = 0.02), peak VO2 (P = 0.008, P = 0.04), and LVEF (P = 0.005, P = 0.002) improved significantly; however, without an additional benefit for either of the groups. Conclusion This randomized multicentre study demonstrates that IMT combined with aerobic training provides additional benefits in functional and serum biomarkers in patients with moderate CHF. These findings advocate for application of IMT in cardiac rehabilitation programmes.
Notes: Laoutaris, ID (reprint author),Onassis Cardiac Surg Ctr, Stress Testing & Rehabil Dept, 356 Sygrou Blv, Athens 17674, Greece, ylaoutaris@yahoo.gr
URI: http://hdl.handle.net/1942/16712
DOI: 10.1002/ejhf.70
ISI #: 000335444200012
ISSN: 1388-9842
Category: A1
Type: Journal Contribution
Validation: ecoom, 2015
Appears in Collections: Research publications

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