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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/16670

Title: Structural modifications of polymethacrylates: Impact on thermal behavior and release characteristics of glassy solid solutions
Authors: Claeys, Bart
De Coen, Ruben
De Geest, Bruno G.
de la Rosa, Victor R.
Hoogenboom, Richard
CARLEER, Robert
ADRIAENSENS, Peter
Remon, Jean Paul
Vervaet, Chris
Issue Date: 2013
Citation: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 85 (3), p. 1206-1214
Abstract: Polymethacrylates such as Eudragit polymers are well established as drug delivery matrix. Here, we synthesize several Eudragit E PO (n-butyl-, dimethylaminoethyl-, methyl-methacrylate-terpolymer) analoguesvia free radical polymerization. These polymers are processed via hot melt extrusion, followed by injection molding and evaluated as carriers to produce immediate release solid solution tablets. Three chemical modifications increased the glass transition temperature of the polymer: (a) substitution of n-butyl by t-butyl groups, (b) reduction of the dimethylaminoethyl methacrylate (DMAEMA) content, and (c) incorporation of a bulky isobornyl repeating unit. These structural modifications revealed the possibility to increase the mechanical stability of the tablets via altering the polymer Tg without influencing the drug release characteristics and glassy solid solution forming properties. The presence of DMAEMA units proved to be crucial with respect to API/polymer interaction (essential in creating glassy solid solutions) and drug release characteristics. Moreover, these chemical modifications accentuate the need for a more rational design of (methacrylate) polymer matrix excipients for drug formulation via hot melt extrusion and injection molding.
URI: http://hdl.handle.net/1942/16670
DOI: 10.1016/j.ejpb.2013.01.027
ISI #: 000330200800043
ISSN: 0939-6411
Category: A1
Type: Journal Contribution
Validation: ecoom, 2015
Appears in Collections: Research publications

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