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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/16546

Title: Long-term effects of prenatal allopurinol treatment on brain plasticity markers in low and normal birth weight piglets.
Authors: VANMIERLO, Tim
Prickaerts, Jos
Gieling, Elise T.
Bruder, Ann K.
van der Staay, Franz J.
Issue Date: 2014
Abstract: In this study, we investigated the effect of antenatal allopurinol (ALLO) treatment on levels and expression of plasticity markers in the dorsal hippocampus of low (LBW) and normal (NBW) birth weight piglets. ALLO treatment given daily in the last trimester to pregnant sows had a protective effect on neuronal plasticity markers in their piglets. ALLO increases protein levels of BDNF and the postsynaptic marker PSD95 in LBW and NBW piglets. ALLO treatment increases the pCREB/CREB ratio in LBW piglets to a similar level as that found in untreated NBW piglets. In conclusion, antioxidant treatment administered in the last trimester might be a promising treatment for LBW neonates.
Notes: Vanmierlo, T (reprint author), Hasselt Univ, Biomed Res Inst, Dept Immunol & Biochem, Agoralaan Bldg C, B-3590 Diepenbeek, Belgium, tim.vanmierlo@uhasselt.be
URI: http://hdl.handle.net/1942/16546
DOI: 10.1016/j.ijdevneu.2013.11.001
ISI #: 000333002800005
ISSN: 0736-5748
Category: A1
Type: Journal Contribution
Validation: ecoom, 2015
Appears in Collections: Research publications

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