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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/16542

Title: High fat diet exacerbates neuroinflammation in an animal model of multiple sclerosis by activation of the Renin Angiotensin system.
Authors: TIMMERMANS, Silke
BOGIE, Jeroen
Lütjohann, Dieter
Hendriks, Jerome J. A.
Issue Date: 2014
Citation: Journal of Neuroimmune Pharmacology, 9 (2), p. 209-217
Abstract: Epidemiological studies suggest a positive correlation between the incidence and severity of multiple sclerosis (MS) and the intake of fatty acids. It remains to be clarified whether high fat diet (HFD) indeed can exacerbate the disease pathology associated with MS and what the underlying mechanisms are. In this study, we determined the influence of HFD on the severity and pathology of experimental autoimmune encephalomyelitis (EAE), an animal model of MS. Mice were fed either normal diet (ND) or HFD and subsequently induced with EAE. Immunohistochemical staining and real-time PCR were used to determine immune cell infiltration and inflammatory mediators in the central nervous system (CNS). Our data show that HFD increases immune cell infiltration and inflammatory mediator production in the CNS and thereby aggravates EAE. Moreover, our data demonstrate that activation of the renin angiotensin system (RAS) is associated with the HFD-mediated effects on EAE severity. These results show that HFD exacerbates an autoreactive immune response within the CNS. This indicates that diets containing excess fat have a significant influence on neuroinflammation in EAE, which may have important implications for the treatment and prevention of neuroinflammatory disorders.
Notes: Hendriks, JJA (reprint author), Hasselt Univ, Transnat Univ Limburg, Sch Life Sci, Biomed Res Inst, Agoralaan Bldg C, B-3590 Diepenbeek, Belgium, Silke.timmermans@uhasselt.be; Jeroen.bogie@uhasselt.be; Tim.vanmierlo@uhasselt.be; Dieter.luetjohann@ukb.uni-bonn.de; Piet.stinissen@uhasselt.be; Niels.hellings@uhasselt.be; Jerome.hendriks@uhasselt.be
URI: http://hdl.handle.net/1942/16542
DOI: 10.1007/s11481-013-9502-4
ISI #: 000333122000013
ISSN: 1557-1890
Category: A1
Type: Journal Contribution
Validation: ecoom, 2015
Appears in Collections: Research publications

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