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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/1654

Title: Differential effects of subthalamic nucleus stimulation in advanced Parkinson disease on reaction time performance
Authors: Temel, Y.
Blokland, A.
Ackermans, Linda
Boon, P.
van Kranen-Mastenbroek, H.
BEULS, Emile
Spincemaille, G.
Visser-Vandewalle, V.
Issue Date: 2006
Publisher: Springer
Citation: EXPERIMENTAL BRAIN RESEARCH, 169(3). p. 389-399
Abstract: The aim of the present study was to assess the effect of bilateral subthalamic nucleus (STN) stimulation and dopaminergic medication on speed of mental processing and motor function. Thirty-nine patients suffering from advanced Parkinson disease (PD) were operated on. Motor function and reaction time (RT) performance [simple RT (SRT) and complex RT (CRT)] were evaluated under four experimental conditions with stimulation (stim) and medication (med) on and off: stim-on/med-on, stim-on/med-off, stim-off/med-off and stim-off/med-on. In the last condition, the patients received either low medication (usual dose) or high medication (suprathreshold dose). STN stimulation improved the motor performance in the SRT and CRT tasks. Furthermore, STN deep brain stimulation (DBS) also improved response preparation as shown by the significant improvement of the RT performance in the SRT task. This effect of STN DBS on the RT performance in the SRT task was greater as compared with the CRT task. This is due to the more complex information processing that is required in the CRT task as compared to the SRT task. These data suggest that treatment of STN hyperactivity by DBS improves motor function, confirming earlier reports, but has a differential effect on cognitive functions. The STN seems to be an important modulator of cognitive processing and STN DBS can differentially affect motor and associative circuits.
URI: http://hdl.handle.net/1942/1654
DOI: 10.1007/s00221-005-0151-6
ISI #: 000235487500010
ISSN: 0014-4819
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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