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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/16501

Title: Comparison of the Mahalanobis Distance and Pearson's χ(2) Statistic as Measures of Similarity of Isotope Patterns.
Authors: ZAMANZAD GHAVIDEL, Fatemeh
CLAESEN, Jurgen
BURZYKOWSKI, Tomasz
VALKENBORG, Dirk
Issue Date: 2014
Citation: JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 25 (2), p. 293-296
Abstract: To extract a genuine peptide signal from a mass spectrum, an observed series of peaks at a particular mass can be compared with the isotope distribution expected for a peptide of that mass. To decide whether the observed series of peaks is similar to the isotope distribution, a similarity measure is needed. In this short communication, we investigate whether the Mahalanobis distance could be an alternative measure for the commonly employed Pearson’s χ2 statistic. We evaluate the performance of the two measures by using a controlled MALDI-TOF experiment. The results indicate that Pearson’s χ2 statistic has better discriminatory performance than the Mahalanobis distance and is a more robust measure.
URI: http://hdl.handle.net/1942/16501
DOI: 10.1007/s13361-013-0773-z
ISI #: 000330828700015
ISSN: 1044-0305
Category: A1
Type: Journal Contribution
Validation: ecoom, 2015
Appears in Collections: Research publications

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