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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/1640

Title: No association of leukemia inhibitory factor (LIF) DNA polymorphisms with multiple sclerosis
Authors: VANDERLOCHT, Joris
BURZYKOWSKI, Tomasz
SOMERS, Veerle
STINISSEN, Piet
HELLINGS, Niels
Issue Date: 2006
Publisher: Elsevier
Citation: JOURNAL OF NEUROIMMUNOLOGY, 171(1-2). p. 189-192
Abstract: Neuropoietins such as leukemia inhibitory factor (LIF) have been shown to ameliorate experimental autoimmune encephalomyelitis (EAE) and promote oligodendrocyte survival in vivo. We tested whether two previously described LIF polymorphisms are associated with MS by genotyping these single nucleotide polymorphisms (SNPs) in a group of MS patients (n = 110), rheumatoid arthritis (RA) patients (n = 120) and healthy controls (HC, n = 109). Similar allele and genotype frequencies for both SNPs were found for all study groups. Furthermore, no associations with MS type or HLA-DR2 expression could be found. In summary, no association was found between the studied LIF DNA polymorphisms and the prevalence of MS indicating that these polymorphisms are not involved in determining disease susceptibility.
URI: http://hdl.handle.net/1942/1640
DOI: 10.1016/j.jneuroim.2005.09.016
ISI #: 000235114500020
ISSN: 0165-5728
Category: A1
Type: Journal Contribution
Validation: ecoom, 2007
Appears in Collections: Research publications

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