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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/16333

Title: Semen quality and prediction of IUI success in male subfertility: a systematic review
Authors: OMBELET, Willem
DHONT, Nathalie
THIJSSEN, Annelies
KRUGER, Thinus
Issue Date: 2014
Abstract: Many variables may influence success rates after intrauterine insemination (IUI), including sperm quality in the native and washed semen sample. A literature search was performed to investigate the threshold levels of sperm parameters above which IUI pregnancy outcome is significantly improved and/or the cut-off values reaching substantial discriminative performance in an IUI programme. A search of MEDLINE, EMBASE and Cochrane Library revealed a total of 983 papers. Only 55 studies (5.6%) fulfilled the inclusion criteria and these papers were analysed. Sperm parameters most frequently examined were: (i) inseminating motile count after washing: cut-off value between 0.8 and 5 million; (ii) sperm morphology using strict criteria: cut-off value 5% normal morphology; (iii) total motile sperm count in the native sperm sample: cut-off value of 5–10 million; and (iv) total motility in the native sperm sample: threshold value of 30%. The results indicate a lack of prospective studies, a lack of standardization in semen testing methodology and a huge heterogeneity of patient groups and IUI treatment strategies. More prospective cohort trials and prospective randomized trials investigating the predictive value of semen parameters on IUI outcome are urgently needed.
Notes: [Ombelet, Willem; Dhont, Nathalie; Thijssen, Annelies; Bosmans, Eugene] Genk Inst Fertil Technol, Dept Obstet & Gynaecol, Genk, Belgium. [Ombelet, Willem; Thijssen, Annelies] Hasselt Univ, Fac Med & Life Sci, Hasselt, Belgium. [Kruger, Thinus] Univ Stellenbosch, Dept Obstet & Gynaecol, Reprod Biol Unit, ZA-7505 Tygerberg, South Africa. [Kruger, Thinus] Tygerberg Hosp, Tygerberg, South Africa.
URI: http://hdl.handle.net/1942/16333
DOI: 10.1016/j.rbmo.2013.10.023
ISI #: 000332413900007
ISSN: 1472-6483
Category: A1
Type: Journal Contribution
Validation: ecoom, 2015
Appears in Collections: Research publications

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