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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/1633

Title: T-cell-based immunotherapy in multiple sclerosis: induction of regulatory immune networks by T-cell vaccination
Authors: HELLINGS, Niels
RAUS, Jef
STINISSEN, Piet
Issue Date: 2006
Publisher: Future drugs
Citation: Expert Review of Clinical Immunology, 2(5). p. 705-716
Abstract: Multiple sclerosis (MS) is a chronic inflammatory disease of the CNS with presumed autoimmune origin. Pathogenic autoimmune responses in MS are thought to be the result of a breakdown of self tolerance. Several mechanisms account for the natural state of immunological tolerance to self antigens, including clonal deletion of self-reactive T cells in the thymus. However, autoimmune T cells are also part of the normal T-cell repertoire, supporting the existence of peripheral regulatory mechanisms that keep these potentially pathogenic T cells under control. One such mechanism involves active suppression by regulatory T cells. It has been indicated that regulatory T cells do not function properly in autoimmune disease. Immunization with attenuated autoreactive T cells, T-cell vaccination, may enhance or restore the regulatory immune networks to specifically suppress autoreactive T cells, as shown in experimental autoimmune encephalomyelitis, an animal model for MS. In the past decade, T-cell vaccination has been tested for MS in several clinical trials. This review summarizes these clinical trials and updates our current knowledge on the induction of regulatory immune networks by T cell vaccination.
URI: http://hdl.handle.net/1942/1633
DOI: 10.1586/1744666X.2.5.705
ISSN: 1744-666X
Category: A2
Type: Journal Contribution
Appears in Collections: Research publications

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