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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/1632

Title: Human papillomavirus and p53 polymorphism in Lithuanian cervical cancer patients
Authors: Gudleviciene, Z.
Didziapetriene, J.
Uleckiene, S.
Valuckas, K.P.
Issue Date: 2006
Publisher: Elsevier
Citation: GYNECOLOGIC ONCOLOGY, 102(3). p. 530-533
Abstract: Background. Cervical cancer is the fourth most common cancer for women in Lithuania. One of the important cervical cancer risk factors is human papillomavirus (HPV) infection. Recent literature has considered p53 allelic polymorphism to be a putative predisposing factor for cervical carcinoma development. Objective. The aim of this study was to elucidate the prevalence of HPV, especially HPV 16, in cervical cancer patients and in healthy women, to investigate the distribution of p53 gene 72 codon polymorphism and to correlate these to cervical cancer risk in Lithuanian women. Methods. 588 women were included in the study: 212 women with primary diagnosed cervical cancer (case group) and 376 healthy volunteers (control group). Results. A high prevalence of HPV DNA was detected in cervical cancer patients, 92.0%, and in control women, 23.6% (P < 0.0001). HPV 16 is the most frequent HPV type in cervical cancer patients. In the case of squamous cell carcinoma, this type was detected in 55.8%, in adenocarcinoma -35.3%. In the control group, this type was detected in 19.0%. A statistically significant difference in the distribution of p53 alleles between the case and the control groups was found. Conclusions. Cervical cancer risk in Lithuanian patients is associated with HPV infection (OR = 75.39; 95% CI 33.61-192.98), especially HPV 16 type (OR = 100.3; 95% CI 46.05-238.59) and p53 homozygous Arg/Arg allele (OR = 2.10; 95% CI 1.10-4.19).
URI: http://hdl.handle.net/1942/1632
DOI: 10.1016/j.ygyno.2006.01.019
ISI #: 000240871000021
ISSN: 0090-8258
Category: A1
Type: Journal Contribution
Validation: ecoom, 2007
Appears in Collections: Research publications

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