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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/1614

Title: Immunoregulation of autoimmunity by natural killer T cells.
Authors: LINSEN, Loes
SOMERS, Veerle
Issue Date: 2005
Publisher: Elsevier
Citation: HUMAN IMMUNOLOGY, 66(12). p. 1193-1202
Abstract: Natural killer T (NKT) cells are a conserved subpopulation of lymphocytes that recognize glycolipid antigens in a CD1d context. Upon activation through their semi-invariant T cell receptor, these cells rapidly release large amounts of immunomodulating Th1 and Th2 cytokines. NKT cells have therefore been implicated in immune responses controlling various diseases, including infection, cancer, transplantation, and autoimmunity. Stimulation of the immunoregulatory capacity of NKT cells by the prototypical antigen α-galactosylceramide results in amelioration of disease in several animal models. This review will focus on the current knowledge of human NKT cells and their role in autoimmune diseases. The features of these cells and their importance in regulation of autoimmunity suggest that NKT cell-based therapies might be an interesting approach for the treatment of autoimmune diseases.
URI: http://hdl.handle.net/1942/1614
DOI: 10.1016/j.humimm.2006.02.020
ISI #: 000238083100001
ISSN: 0198-8859
Category: A1
Type: Journal Contribution
Validation: ecoom, 2007
Appears in Collections: Research publications

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