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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/16135

Title: Sortase A-mediated functionalization of nanobodies toward surface coupling
Authors: TA, Duy Tien
STEEN REDEKER, Erik
GUEDENS, Wanda
ADRIAENSENS, Peter
Issue Date: 2013
Citation: Engineering of Functional Interfaces 2013, Hasselt, 8-9/7/2013
Abstract: The conserved LPETG motif, at which sortase A-catalyzed transpeptidation occurs, is engineered at the C-terminal region of the variable domain of single-domain heavy chain antibody (or nanobody) against Vascular Cell Adhesion Molecule 1 (VCAM1). The recombinant nanobody can then subsequently be ligated, under sortase A catalysis, to a variety of oligoglycine containing targets, including material surfaces, contrast labeling molecules and molecules functionalized for specific chemical coupling reactions.
URI: http://hdl.handle.net/1942/16135
Category: C2
Type: Conference Material
Appears in Collections: Research publications

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