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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/16082

Title: Progression-Free Survival as a Surrogate for Overall Survival in Advanced/Recurrent Gastric Cancer Trials: A Meta-Analysis
Authors: PAOLETTI, Xavier
Oba, Koji
Bang, Yung-Jue
Bleiberg, Harry
Boku, Narikazu
Bouche, Olivier
Fuse, Nozomu
Michiels, Stefan
Moehler, Markus
Morita, Satoshi
Ohashi, Yasuo
Ohtsu, Atsushi
Roth, Arnaud
Rougier, Philippe
Sakamoto, Junichi
Sargent, Daniel
Sasako, Mitsuru
Shitara, Kohei
Thuss-Patience, Peter
Van Cutsem, Eric
BURZYKOWSKI, Tomasz
BUYSE, Marc
Issue Date: 2013
Citation: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 105 (21), p. 1667-1670
Abstract: The traditional endpoint for assessing efficacy of chemotherapies for advanced/recurrent gastric cancer is overall survival (OS), but OS requires prolonged follow-up. We investigated whether progression-free survival (PFS) is a valid surrogate for OS. Using individual patient data from the GASTRIC meta-analysis, surrogacy of PFS was assessed through the correlation between the endpoints and through the correlation between the treatment effects on the endpoints. External validation of the prediction based on PFS was also evaluated. Individual data from 4069 patients in 20 randomized trials were analyzed. The rank correlation coefficient between PFS and OS was 0.853 (95% confidence interval [CI] = 0.852 to 0.854). The R-2 between treatment effects on PFS and on OS was 0.61 (95% CI = 0.04 to 1.00). Treatment effects on PFS and on OS were only moderately correlated, and we could not confirm the validity of PFS as a surrogate endpoint for OS in advanced/recurrent gastric cancer.
URI: http://hdl.handle.net/1942/16082
DOI: 10.1093/jnci/djt269
ISI #: 000326973900013
ISSN: 0027-8874
Category: A1
Type: Journal Contribution
Validation: ecoom, 2014
Appears in Collections: Research publications

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