Document Server@UHasselt >
Research publications >
Please use this identifier to cite or link to this item:
|Title: ||Genetic variation in interleukin-17 receptor A is functionally associated with chronic rejection after lung transplantation|
|Authors: ||Ruttens, David|
Verleden, Stijn E.
Van Raemdonck, Dirk E.
Verleden, Geert M.
Vanaudenaerde, Bart M.
|Issue Date: ||2013|
|Citation: ||JOURNAL OF HEART AND LUNG TRANSPLANTATION, 32 (12), p. 1233-1240|
|Abstract: ||BACKGROUND: Chronic rejection is the major cause of morbidity and mortality after lung transplantation. Interleukin (IL)-17-producing cells, inducers of airway neutrophilia, play a prominent role in chronic rejection. METHODS: We investigated the association between genetic variants in the lL-17/IL-23 pathway and outcome after lung transplantation. Six genetic variants in IL-17 and IL-23 receptor genes were genotyped in 497 lung transplant patients. Associations with chronic rejection, death, airway and systemic inflammatory parameters were assessed. RESULTS: The rs879574A genetic variant in the IL-17A receptor gene was associated with chronic rejection. In particular, carriers of the rs879574 at-risk A allele exhibited increased susceptibility to chronic rejection, with multivariable-adjusted hazard ratio of 1.47 (95% confidence interval, 1.07-2.03; p = 0.004), but no association was found with death (95% confidence interval, 0.71-1.41; p = 0.14). The prevalence of acute rejection was also higher in the at-risk population (p = 0.001). Interestingly, rs879574A was associated with airway neutrophilia (p = 0.020), suggesting that this variant may functionally affect the IL-17A receptor gene and thereby contribute to chronic rejection after lung transplantation. CONCLUSION: The rs879574A genetic variant is associated with chronic rejection after lung transplantation and is functionally associated with airway neutrophilia. Pre-transplant determination of this genetic variant may improve treatment and follow-up of our patients, aiming to reduce acute and chronic rejection. (C) 2013 International Society for Heart and Lung Transplantation. All rights reserved.|
|Notes: ||Vanaudenaerde, BM (reprint author), Katholieke Univ Leuven, Lab Pneumol, Lung Transplantat Unit, Herestr 49, B-3000 Louvain, Belgium.
|ISI #: ||000327688500013|
|Type: ||Journal Contribution|
|Validation: ||ecoom, 2014|
|Appears in Collections: ||Research publications|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.