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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/15994

Title: Biomarkers of human exposure to personal care products: Results from the Flemish Environment and Health Study (FLEHS 2007-2011)
Authors: Den Hond, Elly
Paulussen, Melissa
Geens, Tinne
BRUCKERS, Liesbeth
Baeyens, Willy
David, Frank
Dumont, Emmie
Loots, Ilse
Morrens, Bert
de Bellevaux, Benoit Nemery
Nelen, Vera
Schoeters, Greet
Van Larebeke, Nicolas
Covaci, Adrian
Issue Date: 2013
Citation: SCIENCE OF THE TOTAL ENVIRONMENT, 463, p. 102-110
Abstract: Personal care products (PCPs), such as soaps, perfumes, cosmetics, lotions, etc., contain a variety of chemicals that have been described as potentially hormone disrupting chemicals. Therefore, it is important to assess the internal exposure of these chemicals in humans. Within the 2nd Flemish Environment and Health Study (FLEHS II, 2007-2011), the human exposure to three classes of pollutants that are present in a wide variety of PCPs - i.e. polycyclic musks (galaxolide, HHCB and tonalide, AHTN in blood), parabens (urinary para-hydroxybenzoic acid, HBA) and triclosan (urinary TCS) - was assessed in 210 Flemish adolescents (14-15 years) and in 204 adults (20-40 years) randomly selected from the general population according to a stratified two stage clustered study design. The aim of this study was to define average levels of exposure in the general Flemish population and to identify determinants of exposure. Average levels (GM (95% CI)) in the Flemish adolescents were 0.717 (0.682-0.753) mu g/L for blood HHCB; 0.118 (0.108-0.128) mu g/L for blood AHTN; 1022 (723-1436) mu g/L for urinary HBA and 2.19 (1.64-2.92) mu g/L for urinary TCS. In the adults, levels of HBA were on average 634 (471-970) mu g/L. Inter-individual variability was small for HHCB and AHTN, intermediate for HBA, and large for TCS. All biomarkers were positively associated with the use of PCPs. Additionally, levels of HHCB and AHTN increased with higher educational level of the adolescents. Both in adults and adolescents, urinary HBA levels were negatively correlated with BMI. We define here Flemish exposure values for biomarkers of PCPs, which can serve as baseline exposure levels to identify exposure trends in future biomonitoring campaigns. (C) 2013 Elsevier B.V. All rights reserved.
Notes: Den Hond, E (reprint author), Vlaamse Instelling Technol Onderzoek, Unit Environm Hlth & Risk, Boeretang 200, B-2400 Mol, Belgium. elly.denhond@vito.be
URI: http://hdl.handle.net/1942/15994
DOI: 10.1016/j.scitotenv.2013.05.087
ISI #: 000325831200012
ISSN: 0048-9697
Category: A1
Type: Journal Contribution
Validation: ecoom, 2014
Appears in Collections: Research publications

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