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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/15988

Title: Electrical stimulation of the motor cortex enhances progenitor cell migration in the adult rat brain
Authors: Jahanshahi, Ali
SCHONFELD, Lisa
Janssen, Marcus L. F.
Hescham, Sarah
Kocabicak, Ersoy
Steinbusch, Harry W. M.
van Overbeeke, Jacobus J.
Temel, Yasin
Issue Date: 2013
Citation: EXPERIMENTAL BRAIN RESEARCH, 231 (2), p. 165-177
Abstract: Clinical and preclinical investigations suggest that epidural stimulation of the motor cortex (MC) can improve stroke-induced neurological deficits. The mechanisms involved in stimulation-induced recovery are not well understood and might involve neurogenesis-related processes. Here, we addressed the question whether MC stimulation influences processes of migration and differentiation of neuronal progenitor cells in vivo. Epidural stimulation electrodes were implanted at the level of the MC in rats, and electrical current was applied for a period of 1 month. Increased cell proliferation was observed in the subventricular zone (SVZ). We also found evidences for enhanced cell migration toward the source of current, a process known as electrotaxis. Some of these cells expressed the neuronal marker, NeuN. In addition, our results indicate that MC stimulation enhances neuronal activity of the dorsal raphe nucleus, leading to an increase in the expression of 5-hydroxytryptamine in the SVZ. It is known that such an increase can promote formation of new cells in the SVZ. Our findings suggest that epidural MC stimulation influences neurogenesis-related processes in animal models.
Notes: Jahanshahi, A (reprint author), MUMC, Dept Neurosci, POB 5800, NL-6202 AZ Maastricht, Netherlands. a.jahanshahianvar@maastrichtuniversity.nl; y.temel@maastrichtuniversity.nl
URI: http://hdl.handle.net/1942/15988
DOI: 10.1007/s00221-013-3680-4
ISI #: 000325970600004
ISSN: 0014-4819
Category: A1
Type: Journal Contribution
Validation: ecoom, 2014
Appears in Collections: Research publications

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