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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/15957

Title: Single-center analysis of biopsy-confirmed posttransplant lymphoproliferative disorder: incidence, clinicopathological characteristics and prognostic factors
Authors: Dierickx, Daan
Tousseyn, Thomas
Sagaert, Xavier
Fieuws, Steffen
Wlodarska, Iwona
Morscio, Julie
Brepoels, Lieselot
Kuypers, Dirk
Vanhaecke, Johan
Nevens, Frederik
Verleden, Geert
Van Damme-Lombaerts, Rita
Renard, Marleen
Pirenne, Jacques
De Wolf-Peeters, Christiane
Verhoef, Gregor
Issue Date: 2013
Citation: LEUKEMIA & LYMPHOMA, 54 (11), p. 2433-2440
Abstract: Hematopoietic stem cell and solid organ transplant recipients diagnosed with biopsy-confirmed posttransplant lymphoproliferative disorder (PTLD) at our institution from 1989 to 2010 were identified. Patient-, transplant- and disease-related characteristics, prognostic factors and outcome were collected and analyzed. One hundred and forty biopsy-proven cases of PTLD were included. Overall incidence in the transplant population was 2.12%, with heart transplant recipients carrying the highest risk. Most PTLDs were monomorphic (82%), with diffuse large B-cell lymphoma being the most frequent subtype. The majority of cases (70.7%) occurred >1 year posttransplant, and 66% were Epstein-Barr virus positive. Following initial therapy the overall response rate was 68.5%. Three-year relapse-free and overall survivals were 59% and 49%, respectively. At last follow-up, 44% of the patients were alive. Multivariable analysis identified several classical lymphoma-specific poor prognostic factors for the different outcome measures. The value of the International Prognostic Index was confirmed in our analysis.
Notes: [Dierickx, Daan; Verhoef, Gregor] Dept Hematol, Louvain, Belgium. [Tousseyn, Thomas; Sagaert, Xavier; Morscio, Julie; De Wolf-Peeters, Christiane] KU Leuven Translat Cell & Tissue Res, Louvain, Belgium. [Tousseyn, Thomas; Sagaert, Xavier; Morscio, Julie; De Wolf-Peeters, Christiane] UZ Leuven Dept Pathol, Louvain, Belgium. [Brepoels, Lieselot] Katholieke Univ Leuven Hosp, Dept Nucl Med, B-3000 Louvain, Belgium. [Kuypers, Dirk] Katholieke Univ Leuven Hosp, Dept Nephrol & Renal Transplantat, B-3000 Louvain, Belgium. [Vanhaecke, Johan] Katholieke Univ Leuven Hosp, Dept Cardiol, B-3000 Louvain, Belgium. [Nevens, Frederik] Katholieke Univ Leuven Hosp, Dept Hepatol, B-3000 Louvain, Belgium. [Verleden, Geert] Katholieke Univ Leuven Hosp, Dept Pneumol, B-3000 Louvain, Belgium. [Van Damme-Lombaerts, Rita; Renard, Marleen] Katholieke Univ Leuven Hosp, Dept Pediat, B-3000 Louvain, Belgium. [Pirenne, Jacques] Katholieke Univ Leuven Hosp, Dept Abdominal Transplant Surg, B-3000 Louvain, Belgium. [Fieuws, Steffen] Catholic Univ Louvain, Interuniv Inst Biostat & Stat Bioinformat, B-3000 Louvain, Belgium. [Fieuws, Steffen] Univ Hasselt, Diepenbeek, Belgium. [Wlodarska, Iwona] Catholic Univ Louvain, Ctr Human Genet, B-3000 Louvain, Belgium.
URI: http://hdl.handle.net/1942/15957
DOI: 10.3109/10428194.2013.780655
ISI #: 000325498900018
ISSN: 1042-8194
Category: A1
Type: Journal Contribution
Validation: ecoom, 2014
Appears in Collections: Research publications

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