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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/15913

Title: A single session of 1mA anodal tDCS-supported motor training does not improve motor performance in patients with multiple sclerosis.
Authors: MEESEN, Raf
THIJS, Herbert
LEENUS, Daphnie
Issue Date: 2014
Abstract: Purpose: To assess the effects of atDCS on motor performance in patients with multiple sclerosis (MS). Previously, anodal transcranial direct current stimulation (atDCS) has been shown to improve motor performance in healthy subjects and neurodegenerative populations. However, the effect of atDCS on motor performance is not examined in MS. Methods: In the current study, a sham controlled double-blind crossover design was used to evaluate the effect of 20 minutes of 1mA atDCS or sham tDCS (stDCS) on a unimanual motor sequence-training task, consisting of sequential finger presses on a computer keyboard with the most impaired hand. Patients received stimulation (atDCS or stDCS) during motor training. tDCS was applied over the primary motor cortex contralateral to the most impaired hand. Motor performance was assessed immediately before, during and 30 minutes after stimulation. Results: Although we need to be careful with the interpretation of the data due to lack of power, our results showed no significant effect of atDCS on motor performance. Conclusions: Our findings indicate that atDCS-supported motor training was not able to improve motor performance more than sham-supported motor training. Possibly, the effects of atDCS are mediated by specific MS-related characteristics. Furthermore, increasing atDCS intensity and offering multiple stimulation sessions might be necessary to optimize motor performance resulting from atDCS-supported motor training.
Notes: Cuypers, K (reprint author), Hasselt Univ, REVAL Res Inst, Agoralaan,Bldg A, B-3590 Diepenbeek, Belgium, koen.cuypers@uhasselt.be
URI: http://hdl.handle.net/1942/15913
DOI: 10.3233/RNN-130348
ISI #: 000332478200007
ISSN: 0922-6028
Category: A1
Type: Journal Contribution
Validation: ecoom, 2015
Appears in Collections: Research publications

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