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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/15843

Title: Characterization of biodegradable polymers with capacitive field-effect sensors
Authors: Schusser, S.
Poghossian, A.
Baecker, M.
Leinhos, M.
WAGNER, Patrick
Schoening, M. J.
Issue Date: 2013
Abstract: In vitro studies of the degradation kinetic of biopolymers are essential for the design and optimization of implantable biomedical devices. In the presented work, a field-effect capacitive sensor has been applied for the real-time and in situ monitoring of degradation processes of biopolymers for the first time. The polymer-covered field-effect sensor is, in principle, capable to detect any changes in bulk, surface and interface properties of the polymer induced by degradation processes. The feasibility of this approach has been experimentally proven by using the commercially available biomedical polymer poly(D,L-lactic acid) (PDLLA) as a model system. PDLLA films of different thicknesses were deposited on the Ta2O5-gate surface of the field-effect structure from a polymer solution by means of spin-coating method. The polymer-modified field-effect sensors have been characterized by means of capacitance-voltage and impedance-spectroscopy method. The degradation of the PDLLA was accelerated by changing the degradation medium from neutral (pH 7.2) to alkaline (pH 9) condition, resulting in drastic changes in the capacitance and impedance spectra of the polymer-modified field-effect sensor. (C) 2012 Elsevier B. V. All rights reserved.
Notes: [Schusser, S.; Poghossian, A.; Baecker, M.; Leinhos, M.; Schoening, M. J.] Aachen Univ Appl Sci, Inst Nano & Biotechnol INB, D-52428 Julich, Germany. [Schusser, S.; Poghossian, A.; Baecker, M.; Leinhos, M.; Schoening, M. J.] Forschungszentrum Julich, Peter Grunberg Inst PGI 8, D-52525 Julich, Germany. [Wagner, P.] Hasselt Univ, Inst Mat Res IMO, B-3590 Diepenbeek, Belgium. a.poghossian@fz-juelich.de
URI: http://hdl.handle.net/1942/15843
DOI: 10.1016/j.snb.2012.07.099
ISI #: 000324298300002
ISSN: 0925-4005
Category: A1
Type: Journal Contribution
Validation: ecoom, 2014
Appears in Collections: Research publications

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