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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/15825

Title: Bimanual motor deficits in older adults predicted by diffusion tensor imaging metrics of corpus callosum subregions
Authors: Serbruyns, Leen
Gooijers, Jolien
Caeyenberghs, Karen
Meesen, Raf L.J.
Cuypers, Koen
Sisti, Helene
Alexander, Leemans
Swinnen, Stephan
Issue Date: 2013
Citation: Brain Structure & Function, 220 (1), p. 273-290
Abstract: Age-related changes in the microstructural organization of the corpus callosum (CC) may explain declines in bimanual motor performance associated with normal aging. We used diffusion tensor imaging in young (n = 33) and older (n = 33) adults to investigate the microstructural organization of seven specific CC subregions (prefrontal, premotor, primary motor, primary sensory, parietal, temporal and occipital). A set of bimanual tasks was used to assess various aspects of bimanual motor functioning: the Purdue Pegboard test, simultaneous and alternating finger tapping, a choice reaction time test and a complex visuomotor tracking task. The older adults showed age-related deficits on all measures of bimanual motor performance. Correlation analyses within the older group showed that white matter fractional anisotropy of the CC occipital region was associated with bimanual fine manipulation skills (Purdue Pegboard test), whereas better performance on the other bimanual tasks was related to higher fractional anisotropy in the more anterior premotor, primary motor and primary sensory CC subregions. Such associations were less prominent in the younger group. Our findings suggest that structural alterations of subregional callosal fibers may account for bimanual motor declines in normal aging.
Notes: Swinnen, SP (reprint author), Katholieke Univ Leuven, Biomed Sci Grp, Movement Control & Neuroplast Res Grp, Motor Control Lab, Tervuursevest 101, B-3001 Heverlee, Belgium. Stephan.Swinnen@faber.kuleuven.be
URI: http://hdl.handle.net/1942/15825
DOI: 10.1007/s00429-013-0654-z
ISI #: 000348980800020
ISSN: 1863-2653
Category: A1
Type: Journal Contribution
Validation: ecoom, 2016
Appears in Collections: Research publications

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