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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/15713

Title: The impact of institution variability on patients outcome in a soft tissue sarcoma clinical trial
Authors: Gachau, Susan
Advisors: BURZYKOWSKI, Tomasz
LITIERE, Saskia
Issue Date: 2013
Publisher: tUL
Abstract: ABSTRACT Background: Soft-tissue sarcomas (STS) are a rare and heterogeneous group of tumors of mesenchymal origin and can start in any part of the body mainly in support and connective tissues. When performing large multicenter clinical trials, a lot of attention is paid to the standardization of the treatment procedures across the participating sites. This is done to ensure that the difference in effect observed between treatment arms, can be completely attributed to the difference in treatments. This is because heterogeneity between the participating centers may add noise to the estimation of the treatment effect. Objective: The overall objective was to investigate the impact of institution variability on patient outcome in a soft tissue sarcoma clinical trial. Specifically, to compare parameter estimates from different statistical analysis methods as well as investigate the impact of frailty misspecification on parameters of interest. Methods: In statistical analysis, semi
Notes: Master of Statistics-Biostatistics
URI: http://hdl.handle.net/1942/15713
Category: T2
Type: Theses and Dissertations
Appears in Collections: Master theses

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