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|Title: ||Prevalence and spread of multidrug-resistant Escherichia coli including ST131 in different patient populations in the Euroregion Meuse-Rhine|
|Authors: ||van der Donk, Christina|
van de Bovenkamp, Jeroen
|Issue Date: ||2013|
|Citation: ||FUTURE MICROBIOLOGY, 8 (8), p. 1027-1037|
|Abstract: ||Aim: To investigate the prevalence and genetic background of Escherichia coli collected from different patient populations in the Euroregion Meuse-Rhine. Materials & methods: Susceptibility testing was performed on 1651 E. coli isolates with broth microdilution. Their genetic background was determined using pulsed-field gel electrophoresis and multilocus sequence typing. Results: The prevalence of resistance varied significantly between the populations. Approximately 10% of the E. coli isolates were multidrug-resistant and/or a β-lactamase producer. The most prevalent extended-spectrum β-lactamase type was CTX-M-15 and ST131 was the most prevalent multilocus sequence typing type. Results from pulsed-field gel electrophoresis of the ST131 isolates indicate the spread of these isolates in the Euroregion. Conclusion: E. coli ST131 was the most prevalent sequence type in our Euroregional study. It is essential to control the spread of these resistant strains (e.g., with infection-control policies, antibiotic stewardship programs and antibiotic resistance surveillance). In this way we could observe shifts in the prevalence of resistance of the E. coli population and act accordingly.|
|Notes: ||Stobberingh, E (reprint author), Maastricht Univ, Dept Med Microbiol, Med Ctr, P Debyelaan 25, NL-6229 HX Maastricht, Netherlands.
|ISI #: ||000323229800014|
|Type: ||Journal Contribution|
|Appears in Collections: ||Research publications|
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