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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/15482

Title: Systemic Immune Activation Leads to Neuroinflammation and Sickness Behavior in Mice
Authors: BIESMANS, Steven
Meert, Theo F.
Bouwknecht, Jan A.
Acton, Paul D.
DAVOODI, Nima
De Haes, Patrick
KUIJLAARS, Jacobine
Langlois, Xavier
Matthews, Liam J. R.
Donck, Luc Ver
HELLINGS, Niels
Nuydens, Rony
Issue Date: 2013
Publisher: HINDAWI PUBLISHING CORPORATION
Citation: MEDIATORS OF INFLAMMATION, 2013, (ART N° 271359)
Abstract: Substantial evidence indicates an association between clinical depression and altered immune function. Systemic administration of bacterial lipopolysaccharide (LPS) is commonly used to study inflammation-associated behavioral changes in rodents. In these experiments, we tested the hypothesis that peripheral immune activation leads to neuroinflammation and depressive-like behavior in mice. We report that systemic administration of LPS induced astrocyte activation in transgenic GFAP-luc mice and increased immunoreactivity against the microglial marker ionized calcium-binding adapter molecule 1 in the dentate gyrus of wild-type mice. Furthermore, LPS treatment caused a strong but transient increase in cytokine levels in the serum and brain. In addition to studying LPS-induced neuroinflammation, we tested whether sickness could be separated from depressive-like behavior by evaluating LPS-treated mice in a panel of behavioral paradigms. Our behavioral data indicate that systemic LPS administration caused sickness and mild depressive-like behavior. However, due to the overlapping time course and mild effects on depression-related behavior per se, it was not possible to separate sickness from depressive-like behavior in the present rodent model.
Notes: [Biesmans, Steven; Meert, Theo F.; Davoodi, Nima; Hellings, Niels] Hasselt Univ, BIOMED, B-3590 Diepenbeek, Belgium. [Biesmans, Steven; Meert, Theo F.; Bouwknecht, Jan A.; Davoodi, Nima; De Haes, Patrick; Kuijlaars, Jacobine; Langlois, Xavier; Matthews, Liam J. R.; Donck, Luc Ver; Nuydens, Rony] Janssen Res & Dev, Div Janssen Pharmaceut NV, Neurosci, B-2340 Beerse, Belgium. [Acton, Paul D.] Janssen Res & Dev LLC, Mol Imaging, Spring House, PA 19477 USA.
URI: http://hdl.handle.net/1942/15482
DOI: 10.1155/2013/271359
ISI #: 000322395400001
ISSN: 0962-9351
Category: A1
Type: Journal Contribution
Validation: ecoom, 2014
Appears in Collections: Research publications

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