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|Title: ||Systemic Immune Activation Leads to Neuroinflammation and Sickness Behavior in Mice|
|Authors: ||BIESMANS, Steven|
Meert, Theo F.
Bouwknecht, Jan A.
Acton, Paul D.
De Haes, Patrick
Matthews, Liam J. R.
Donck, Luc Ver
|Issue Date: ||2013|
|Publisher: ||HINDAWI PUBLISHING CORPORATION|
|Citation: ||MEDIATORS OF INFLAMMATION, 2013, (ART N° 271359)|
|Abstract: ||Substantial evidence indicates an association between clinical depression and altered immune function. Systemic administration of bacterial lipopolysaccharide (LPS) is commonly used to study inflammation-associated behavioral changes in rodents. In these experiments, we tested the hypothesis that peripheral immune activation leads to neuroinflammation and depressive-like behavior in mice. We report that systemic administration of LPS induced astrocyte activation in transgenic GFAP-luc mice and increased immunoreactivity against the microglial marker ionized calcium-binding adapter molecule 1 in the dentate gyrus of wild-type mice. Furthermore, LPS treatment caused a strong but transient increase in cytokine levels in the serum and brain. In addition to studying LPS-induced neuroinflammation, we tested whether sickness could be separated from depressive-like behavior by evaluating LPS-treated mice in a panel of behavioral paradigms. Our behavioral data indicate that systemic LPS administration caused sickness and mild depressive-like behavior. However, due to the overlapping time course and mild effects on depression-related behavior per se, it was not possible to separate sickness from depressive-like behavior in the present rodent model.|
|Notes: ||[Biesmans, Steven; Meert, Theo F.; Davoodi, Nima; Hellings, Niels] Hasselt Univ, BIOMED, B-3590 Diepenbeek, Belgium. [Biesmans, Steven; Meert, Theo F.; Bouwknecht, Jan A.; Davoodi, Nima; De Haes, Patrick; Kuijlaars, Jacobine; Langlois, Xavier; Matthews, Liam J. R.; Donck, Luc Ver; Nuydens, Rony] Janssen Res & Dev, Div Janssen Pharmaceut NV, Neurosci, B-2340 Beerse, Belgium. [Acton, Paul D.] Janssen Res & Dev LLC, Mol Imaging, Spring House, PA 19477 USA.|
|ISI #: ||000322395400001|
|Type: ||Journal Contribution|
|Validation: ||ecoom, 2014|
|Appears in Collections: ||Research publications|
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