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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/15462

Title: Herpes Zoster Risk Reduction through Exposure to Chickenpox Patients: A Systematic Multidisciplinary Review
Authors: OGUNJIMI, Benson
Van Damme, Pierre
Beutels, Philippe
Issue Date: 2013
Citation: PLOS ONE, 8 (6)
Abstract: Varicella-zoster virus (VZV) causes chickenpox and may subsequently reactivate to cause herpes zoster later in life. The exogenous boosting hypothesis states that re-exposure to circulating VZV can inhibit VZV reactivation and consequently also herpes zoster in VZV-immune individuals. Using this hypothesis, mathematical models predicted widespread chickenpox vaccination to increase herpes zoster incidence over more than 30 years. Some countries have postponed universal chickenpox vaccination, at least partially based on this prediction. After a systematic search and selection procedure, we analyzed different types of exogenous boosting studies. We graded 13 observational studies on herpes zoster incidence after widespread chickenpox vaccination, 4 longitudinal studies on VZV immunity after re-exposure, 9 epidemiological risk factor studies, 7 mathematical modeling studies as well as 7 other studies. We conclude that exogenous boosting exists, although not for all persons, nor in all situations. Its magnitude is yet to be determined adequately in any study field.
Notes: [Ogunjimi, Benson; Beutels, Philippe] Univ Antwerp, Ctr Hlth Econ Res & Modeling Infect Dis, Vaccine & Infect Dis Inst, B-2020 Antwerp, Belgium. [Ogunjimi, Benson] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat, Hasselt, Belgium. [Van Damme, Pierre] Univ Antwerp, Vaccine & Infect Dis Inst, Ctr Evaluat Vaccinat, B-2020 Antwerp, Belgium. [Beutels, Philippe] Univ New S Wales, Sch Publ Hlth & Community Med, Sydney, NSW, Australia. benson.ogunjimi@ua.ac.be
URI: http://hdl.handle.net/1942/15462
DOI: 10.1371/journal.pone.0066485
ISI #: 000320846500052
ISSN: 1932-6203
Category: A1
Type: Journal Contribution
Validation: ecoom, 2014
Appears in Collections: Research publications

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