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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/15448

Title: Cell proliferation monitoring by multiplexed electrochemical impedance spectroscopy on microwell assays
Authors: Duchateau, Stijn
Broeders, Jeroen
Croux, Dieter
Rigo, Jean-Michel
Wagner, Patrick
Thoelen, Ronald
De Ceuninck, Ward
Issue Date: 2013
Citation: Physica Status Solidi C, 10 (5), p. 882-888
Abstract: Cell proliferation can be monitored by a wide range of well-established techniques. Most of the principles used rely on optical, single end-point methods, often involving the use of absorbent, fluorescent or luminescent compounds. These additives can interfere with the cell growth, thus producing distorted results. Electrochemical impedance spectroscopy provides a solution for this problem and enables continuous monitoring without interference. However equipment for this measurement technique is often bulky, highly expensive and lacks multichannel features. This paper presents a low-cost, compact hardware platform optimized for proliferation measurements, together with custom software to ease interpretation and physical modelling of data. Performance is demonstrated and measurement parameters are fine-tuned for three commonly used cell types in proliferation measurements.
Notes: Duchateau, S (reprint author), Xios Univ Coll, Agoralaan Gebouw H, B-3590 Diepenbeek, Belgium. stijn.duchateau@uhasselt.be
URI: http://hdl.handle.net/1942/15448
DOI: 10.1002/pssc.201200748
ISI #: 000322514100038
ISSN: 1862-6351
Category: A1
Type: Journal Contribution
Validation: ecoom, 2014
Appears in Collections: Research publications

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