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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/15424

Title: Impedance spectroscopy: A tool for real-time in situ monitoring of the degradation of biopolymers
Authors: Schusser, Sebastian
Leinhos, Marcel
Baecker, Matthias
Poghossian, Arshak
Wagner, Patrick
Schoening, Michael J.
Issue Date: 2013
Publisher: WILEY-V C H VERLAG GMBH
Citation: PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE, 210 (5), p. 905-910
Abstract: Investigation of the degradation kinetics of biodegradable polymers is essential for the development of implantable biomedical devices with predicted biodegradability. In this work, an impedimetric sensor has been applied for real-time and in situ monitoring of degradation processes of biopolymers. The sensor consists of two platinum thin-film electrodes covered by a polymer film to be studied. The benchmark biomedical polymer poly(D,L-lactic acid) (PDLLA) was used as a model system. PDLLA films were deposited on the sensor structure from a polymer solution by using the spin-coating method. The degradation kinetics of PDLLA films have been studied in alkaline solutions of pH 9 and 12 by means of an impedance spectroscopy (IS) method. Any changes in a polymer capacitance/resistance induced by water uptake and/or polymer degradation will modulate the global impedance of the polymer-covered sensor that can be used as an indicator of the polymer degradation. The degradation rate can be evaluated from the time-dependent impedance spectra. As expected, a faster degradation has been observed for PDLLA films exposed to pH 12 solution.
Notes: Aachen Univ Appl Sci, Inst Nano & Biotechnol INB, D-52428 Julich, Germany. Forschungszentrum Julich, Peter Grunberg Inst PGI 8, D-52425 Julich, Germany. Hasselt Univ, Inst Mat Res, B-3590 Diepenbeek, Belgium.
URI: http://hdl.handle.net/1942/15424
DOI: 10.1002/pssa.201200941
ISI #: 000319151900013
ISSN: 1862-6300
Category: A1
Type: Journal Contribution
Validation: ecoom, 2014
Appears in Collections: Research publications

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