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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/15370

Title: A critical comparison of cell-based sensor systems for the detection of Cr(VI) in aquatic environment
Authors: BOHRN, Ulrich
Mucha, Andreas
Werner, Carl Frederik
Trattner, Barbara
Baecker, Matthias
Krumbe, Christoph
Schienle, Meinrad
Stuetz, Evamaria
Schmitt-Landsiedel, Doris
Fleischer, Maximilian
WAGNER, Patrick
Schoening, Michael J.
Issue Date: 2013
Abstract: The toxicity of chromium ions was investigated using mammalian cell cultures on impedance sensors as well as physiological in vitro sensor systems. The performance of commercially available systems like the 2500 Analyzing System (Bionas), xCELLigence (Roche) and Cytosensor Microphysiometer (Molecular Devices) was compared with a novel CMOS-based impedance-to-frequency converter device. Cell-based sensor systems are shown to be powerful tools to detect Cr(VI) pollutions within several hours in the range of multinational drinking water regulations. The ability to distinguish between toxic Cr(VI) and non-toxic Cr(III) species is one advantage of these integral sensor systems. Impedance only devices are not sufficient for the fast detection of toxic chromium species as rapid cellular changes occur only in the respiration system and the cell physiology. (C) 2013 Elsevier B.V. All rights reserved.
Notes: Bohrn, U (reprint author), Siemens AG, Corp Res & Technol, D-81379 Munich, Germany. Univ Appl Sci Aachen, Inst Nano & Biotechnol, D-52428 Julich, Germany. Hasselt Univ, Inst Mat Sci IMO IMOMEC, B-3590 Diepenbeek, Belgium. Univ Munich, Div Neurobiol, D-82152 Martinsried, Germany. Tech Univ Munich, Lehrstuhl Tech Elekt, D-80333 Munich, Germany. ulrichbohrn@hotmail.com
URI: http://hdl.handle.net/1942/15370
DOI: 10.1016/j.snb.2013.02.105
ISI #: 000319488800009
ISSN: 0925-4005
Category: A1
Type: Journal Contribution
Validation: ecoom, 2014
Appears in Collections: Research publications

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