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|Title: ||A critical comparison of cell-based sensor systems for the detection of Cr(VI) in aquatic environment|
|Authors: ||BOHRN, Ulrich|
Werner, Carl Frederik
Schoening, Michael J.
|Issue Date: ||2013|
|Publisher: ||ELSEVIER SCIENCE SA|
|Citation: ||SENSORS AND ACTUATORS B-CHEMICAL, 182, p. 58-65|
|Abstract: ||The toxicity of chromium ions was investigated using mammalian cell cultures on impedance sensors as well as physiological in vitro sensor systems. The performance of commercially available systems like the 2500 Analyzing System (Bionas), xCELLigence (Roche) and Cytosensor Microphysiometer (Molecular Devices) was compared with a novel CMOS-based impedance-to-frequency converter device. Cell-based sensor systems are shown to be powerful tools to detect Cr(VI) pollutions within several hours in the range of multinational drinking water regulations. The ability to distinguish between toxic Cr(VI) and non-toxic Cr(III) species is one advantage of these integral sensor systems. Impedance only devices are not sufficient for the fast detection of toxic chromium species as rapid cellular changes occur only in the respiration system and the cell physiology. (C) 2013 Elsevier B.V. All rights reserved.|
|Notes: ||Bohrn, U (reprint author), Siemens AG, Corp Res & Technol, D-81379 Munich, Germany. Univ Appl Sci Aachen, Inst Nano & Biotechnol, D-52428 Julich, Germany. Hasselt Univ, Inst Mat Sci IMO IMOMEC, B-3590 Diepenbeek, Belgium. Univ Munich, Div Neurobiol, D-82152 Martinsried, Germany. Tech Univ Munich, Lehrstuhl Tech Elekt, D-80333 Munich, Germany.
|ISI #: ||000319488800009|
|Type: ||Journal Contribution|
|Validation: ||ecoom, 2014|
|Appears in Collections: ||Research publications|
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