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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/15331

Title: Screening for potential hazard effects from four nitramines on human eye and skin
Authors: Fjellsbo, Lise Marie
Van Rompay, An R.
HOOYBERGHS, Jef
Nelissen, Inge
Dusinska, Maria
Issue Date: 2013
Publisher: PERGAMON-ELSEVIER SCIENCE LTD
Citation: TOXICOLOGY IN VITRO, 27 (4), p. 1205-1210
Abstract: Amines have potential to be used in CO2 capture and storage (CCS) technology, but as they can be released into the environment and be degraded into more toxic compounds, such as nitrosamines and nitramines, there have been concerns about their negative impact on human health. We investigated the potential toxic effects from acute exposure to dimethylnitramine (DMA-NO2), methylnitramine (MA-NO2), ethanolnitramine (MEA-NO2) and 2-methyl-2-(nitroamino)-1-propanol (AMP-NO2). The eye irritation, and skin sensitization, irritation and corrosion potential of these substances have been evaluated in vitro using the Bovine Corneal Opacity and Permeability (BCOP) assay, VITOSENS (R) assay, Reconstructed Human Epidermis (RHE) skin irritation test and Corrositex Skin corrosion test, respectively. Exposure to DMA-NO2 induced a mild eye irritation response, while MA-NO2, MEA-NO2 and AMP-NO2 were shown to be very severe eye irritants. MA-NO2 and MEA-NO2 were tested for skin sensitization and found to be non-sensitizers to the skin. In addition, none of the four test substances was irritant or corrosive to the skin. (C) 2013 Elsevier Ltd. All rights reserved.
Notes: Dusinska, M (reprint author), NILU Norwegian Inst Air Res, Dept Environm Chem, Hlth Effects Lab, Kjeller, Norway. Flemish Inst Technol Res VITO, Environm Risk & Hlth Unit, Mol, Belgium. Hasselt Univ, Dept Math Phys & Informat, Hasselt, Belgium. maria.dusinska@nilu.no
URI: http://hdl.handle.net/1942/15331
DOI: 10.1016/j.tiv.2013.02.004
ISI #: 000318838000003
ISSN: 0887-2333
Category: A1
Type: Journal Contribution
Validation: ecoom, 2014
Appears in Collections: Research publications

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