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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/14850

Title: Statin use and the presence of microalbuminuria. Results from the ERICABEL trial: a non-interventional epidemiological cohort study
Authors: van der Tol, Arjan
Van Biesen, Wim
Van Laecke, Steven
Bogaerts, Kris
De Lombaert, Koen
Warrinnier, Hans
Vanholder, Raymond
Issue Date: 2012
Citation: PLoS One, 7 (2), p. e31639
Abstract: Microalbuminuria (MAU) is considered as a predictor or marker of cardiovascular and renal events. Statins are widely prescribed to reduce cardiovascular risk and to slow down progression of kidney disease. But statins may also generate tubular MAU. The current observational study evaluated the impact of statin use on the interpretation of MAU as a predictor or marker of cardiovascular or renal disease. Methodology/Principal Findings: We used cross-sectional data of ERICABEL, a cohort with 1,076 hypertensive patients. MAU was defined as albuminuria ≥20 mg/l. A propensity score was created to correct for “bias by indication” to receive a statin. As expected, subjects using statins vs. no statins had more cardiovascular risk factors, pointing to bias by indication. Statin users were more likely to have MAU (OR: 2.01, 95%CI: 1.34–3.01). The association between statin use and MAU remained significant after adjusting for the propensity to receive a statin based on cardiovascular risk factors (OR: 1.82, 95%CI: 1.14–2.91). Next to statin use, only diabetes (OR: 1.92, 95%CI: 1.00–3.66) and smoking (OR: 1.49, 95%CI: 0.99–2.26) were associated with MAU. Conclusions: Use of statins is independently associated with MAU, even after adjusting for bias by indication to receive a statin. In the hypothesis that this MAU is of tubular origin, statin use can result in incorrect labeling of subjects as having a predictor or marker of cardiovascular or renal risk. In addition, statin use affected the association of established cardiovascular risk factors with MAU, blurring the interpretation of multivariable analyses.
URI: http://hdl.handle.net/1942/14850
DOI: 10.1371/journal.pone.0031639
ISI #: 000302796200080
ISSN: 1932-6203
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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