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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/14729

Title: Simultaneous Inferences for Ratio Parameters Using Multiple Contrasts Test
Authors: Lin, Dan
Djira, Gemechis D.
Shkedy, Ziv
Burzykowski, Tomasz
Hothorn, Ludwig A.
Issue Date: 2012
Publisher: Springer
Citation: Lin, D.; Shkedy, Z.; Yekutieli, D.; Amaratunga, D.; Bijnens, L. (Ed.). Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R: Order-Restricted Analysis of Microarray Data, p. 249-258
Series/Report: Use R!
Abstract: In chap.16, we wish to search for genes for which the mean gene-expression increases by 100 ×δ% from the control for at least one (perhaps the highest) dose, where δ is a relative biological ratio of interest. Genes can be tested for a pre-specified δ and can be ranked based on the significance of the ratio test. Genes found significant with a large δ are of higher interest to the biologists. We discuss the ratio test statistic and the link between Williams- and Marcus-type multiple contrasts tests (MCTs) and the corresponding ratio testing procedures.
URI: http://hdl.handle.net/1942/14729
Link to publication: http://www.ibiostat.be/software/IsoGeneGUI/Book.html
DOI: 10.1007/978-3-642-24007-2_16
ISBN: 9783642240065
ISSN: 2197-5736
Category: B2
Type: Book Section
Appears in Collections: Research publications

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