Document Server@UHasselt >
Research >
Research publications >

Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/14646

Title: The role of "anti-inflammatory" cytokines in axon regeneration
Authors: Vidal, Pia M.
Lemmens, Evi
Dooley, Dearbhaile
Hendrix, Sven
Issue Date: 2012
Citation: CYTOKINE & GROWTH FACTOR REVIEWS, 24 (1), p. 1-12
Abstract: The injured central and peripheral nervous system (CNS and PNS) are difficult to regenerate due to the presence of growth inhibitory molecules which are upregulated around the lesion site. In addition, a strong inflammatory response triggering the production of so-called "pro"- and "anti-inflammatory" cytokine, adds to this dilemma. Both pro- and anti-inflammatory cytokines are involved in the regulation of diverse signalling pathways. One of the main aims to induce regeneration is to promote axonal outgrowth and stimulate the formation of new connections. Anti-inflammatory cytokines as modulators of neurite plasticity and outgrowth are of pivotal importance in neuroregeneration with different effects reported. Here we summarize the most relevant information about IL-4, IL-10, IL-13, LIF and TGF-β focusing on their direct and indirect role in axonal outgrowth.
URI: http://hdl.handle.net/1942/14646
DOI: 10.1016/j.cytogfr.2012.08.008
ISI #: 000316436200001
ISSN: 1359-6101
Category: A1
Type: Journal Contribution
Validation: ecoom, 2014
Appears in Collections: Research publications

Files in This Item:

Description SizeFormat
N/A533.52 kBAdobe PDF

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.