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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/1461

Title: Development Of Starch-Based Pellets Via Extrusion/Spheronisation
Authors: Dukic, A.
MENS, Raoul
ADRIAENSENS, Peter
Foreman, P.
GELAN, Jan
Remon, J.P.
Vervaet, C.
Issue Date: 2006
Publisher: Elsevier
Citation: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 66(1). p. 83-94
Abstract: A modified starch (high-amylose, crystalline and resistant starch) was evaluated as an alternative excipient to microcrystalline cellulose for pellets prepared via extrusion/spheronisation. Theophylline anhydrous (25%, w/w) was used as a model drug. A binder was necessary to obtain an acceptable yield and the addition of sorbitol improved the surface properties of the pellets. A surface response design with three formulation variables (binder, sorbitol and water level) and one process variable (spheronisation speed) was used to optimise the process and to evaluate pellet yield, sphericity (aspect ratio and two-dimensional shape factor, eR), size (mean Feret diameter), friability and disintegration
URI: http://hdl.handle.net/1942/1461
DOI: 10.1016/j.ejpb.2006.08.015
ISI #: 000245788500011
ISSN: 0939-6411
Category: A1
Type: Journal Contribution
Validation: ecoom, 2008
Appears in Collections: Research publications

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