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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/14412

Title: Novel cerebrospinal fluid and serum autoantibody targets for clinically isolated syndrome
Authors: ROUWETTE, Myrthe
SOMERS, Klaartje
GOVARTS, Cindy
De Deyn, Peter P.
Hupperts, Raymond
VAN WIJMEERSCH, Bart
De Jong, Brigit A.
Verbeek, Marcel M.
Van Pesch, Vincent
Sindic, Christian
Villar, Luisa M.
Alvarez-Cermeno, Jose C.
STINISSEN, Piet
SOMERS, Veerle
Issue Date: 2012
Publisher: WILEY-BLACKWELL
Citation: JOURNAL OF NEUROCHEMISTRY, 123 (4), p. 568-577
Abstract: Limited information is available on the identity of antigens targeted by antibodies present in cerebrospinal fluid (CSF) of patients with clinically isolated syndrome (CIS). The aim of this study was to identify novel antigens for CIS and investigate their prognostic potential to predict conversion to multiple sclerosis (MS). We applied serological antigen selection (SAS) to identify antigens interacting with antibodies present in the pooled CSF from four CIS patients, who developed MS. Antibody reactivity towards CIS antigens identified by SAS was tested in CSF and serum from patients with CIS (n = 123/n = 108), MS (n = 65/n = 44), and other (inflammatory) neurological diseases (n = 75/n = 38) as well as in healthy control sera (n = 44). Using SAS, a panel of six novel CIS candidate antigens was identified. CSF antibody reactivity was detected in both CIS and relapsing-remitting (RR) MS. Serum reactivity was significantly increased in CIS and RR-MS as compared with controls (p = 0.03). For two antigens, the frequency of antibody-positive patients was higher in CIS patients who converted to MS as compared with CIS patients without conversion. We identified novel CIS antigens to which antibody reactivity was primarily detected in CIS and RR-MS as compared to controls. Possible prognostic potential could be demonstrated for two antigens.
Notes: [Rouwette, Myrthe; Somers, Klaartje; Govarts, Cindy; Van Wijmeersch, Bart; Stinissen, Piet; Somers, Veerle] Hasselt Univ, Biomed Res Inst BIOMED, B-3590 Diepenbeek, Belgium. [Rouwette, Myrthe; Somers, Klaartje; Govarts, Cindy; Van Wijmeersch, Bart; Stinissen, Piet; Somers, Veerle] Transnat Univ Limburg, Sch Life Sci, B-3590 Diepenbeek, Belgium. [De Deyn, Peter P.] Middelheim Hosp, Dept Neurol, Antwerp, Belgium. [De Deyn, Peter P.] Univ Antwerp, Lab Neurochem & Behav, Dept Biomed Sci, Inst Born Bunge, B-2020 Antwerp, Belgium. [De Deyn, Peter P.] Univ Med Ctr Groningen, Dept Neurol, NL-9713 AV Groningen, Netherlands. [Hupperts, Raymond] Maastricht Univ, Med Ctr, Sch Mental Hlth & Neurosci, Maastricht, Netherlands. [Hupperts, Raymond] Orbis Med Ctr, Dept Neurol, Sittard, Netherlands. [Van Wijmeersch, Bart] Multiple Sclerosis & Rehabil Ctr, Overpelt, Belgium. [De Jong, Brigit A.] Radboud Univ Nijmegen, Med Ctr, MSCN, NL-6525 ED Nijmegen, Netherlands. [De Jong, Brigit A.; Verbeek, Marcel M.] Radboud Univ Nijmegen, Med Ctr, Dept Neurol, NL-6525 ED Nijmegen, Netherlands. [Verbeek, Marcel M.] Radboud Univ Nijmegen, Med Ctr, Dept Lab Med, NL-6525 ED Nijmegen, Netherlands. [Van Pesch, Vincent; Sindic, Christian] Catholic Univ Louvain, Dept Neurol, Clin Univ St Luc, B-1200 Brussels, Belgium. [Villar, Luisa M.; Alvarez-Cermeno, Jose C.] Hosp Ramon & Cajal, Dept Neurol, E-28034 Madrid, Spain. [Villar, Luisa M.; Alvarez-Cermeno, Jose C.] Hosp Ramon & Cajal, Dept Immunol, E-28034 Madrid, Spain.
URI: http://hdl.handle.net/1942/14412
DOI: 10.1111/jnc.12005
ISI #: 000309916900011
ISSN: 0022-3042
Category: A1
Type: Journal Contribution
Validation: ecoom, 2013
Appears in Collections: Research publications

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