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|Title: ||The effect of histamine, a traumatic brain injury mediator, on the function of aquaporin-4 in rat brain in vivo|
|Authors: ||Smets, A.|
De Jongh, R.
Timmermans, J. P.
Rigo, J. M.
|Issue Date: ||2009|
|Publisher: ||MEDIMOND S R L|
|Citation: ||Baron, A; Chneiweiss, H (Ed.). 9TH EUROPEAN MEETING ON GLIAL CELLS IN HEALTH AND DISEASE, p. 153-156|
|Abstract: ||The high levels of histamine in brain after traumatic brain injury and the observed influence of histamine on aquaporin-1 (AQP-1) localization in gastric cells, lead to the hypothesis that histamine could play a major role in the pathophysiology of brain edema An intracerebroventricular (ICV) histamine induced brain edema model was developed in rats. Infusion of concentrations >= 50 mM histamine resulted in a dose-dependent intracranial pressure (ICP) increase and death. Furthermore, histological experiments showed the internalization of membrane-expressed AQP4 after histamine challenge. The decreased fraction of functional membrane-associated AQP4 might result in an increased intracranial p[ressure. In this new experimental rat mode, the functional activity of novel treatment options for increased ICP, IV or ICV administration, can readily be tested.|
|Notes: ||Address: Smets, A (reprint author), Univ Hasselt, Biomed Res Unit BIOMED, Diepenbeek, Belgium.|
|ISI #: ||000292191900030|
|Type: ||Proceedings Paper|
|Validation: ||ecoom, 2012|
|Appears in Collections: ||Research publications|
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