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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/14339

Title: Analysis of an optical biosensor based on elastic light scattering from diamond-, glass-, and sapphire microspheres
Authors: MURIB, Mohammed Sharif
Tran, Anh Quang
DE CEUNINCK, Ward
Schöning, J.M.
NESLADEK, Milos
Serpengüzel, Ali
WAGNER, Patrick
Issue Date: 2012
Publisher: WILEY-V C H VERLAG GMBH
Citation: PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE, 209 (9), p. 1804-1810
Abstract: Deoxyribonucleic acid (DNA) and protein recognition are now standard tools in biology. In addition, the special optical properties of microsphere resonators expressed by the high quality factor (Q-factor) of whispering gallery modes (WGMs) or morphology dependent resonances (MDRs) have attracted the attention of the biophotonic community. Microsphere-based biosensors are considered as powerful candidates to achieve label-free recognition of single molecules due to the high sensitivity of their WGMs. When the microsphere surface is modified with biomolecules, the effective refractive index and the effective size of the microsphere change resulting in a resonant wavelength shift. The transverse electric (TE) and the transverse magnetic (TM) elastic light scattering intensity of electromagnetic waves at 600 and 1400?nm are numerically calculated for DNA and unspecific binding of proteins to the microsphere surface. The effect of changing the optical properties was studied for diamond (refractive index 2.34), glass (refractive index 1.50), and sapphire (refractive index 1.75) microspheres with a 50 mu m radius. The mode spacing, the linewidth of WGMs, and the shift of resonant wavelength due to the change in radius and refractive index, were analyzed by numerical simulations. Preliminary results of unspecific binding of biomolecules are presented. The calculated shift in WGMs can be used for biomolecules detection.
Notes: [Murib, Mohammed S.; Anh Quang Tran; De Ceuninck, Ward; Nesladek, Milos; Wagner, Patrick] Hasselt Univ, Inst Mat Res, IMO, B-3590 Diepenbeek, Belgium. [De Ceuninck, Ward; Nesladek, Milos; Wagner, Patrick] IMEC VZW, Div IMOMEC, B-3590 Diepenbeek, Belgium. [Schoening, Michael J.] Aachen Univ Appl Sci, Inst Nano & Biotechnol, D-52428 Julich, Germany. [Serpenguzel, Ali] Koc Univ, Dept Phys, Microphoton Res Lab, TR-34450 Istanbul, Turkey. mohammed.murib@uhasselt.be
URI: http://hdl.handle.net/1942/14339
DOI: 10.1002/pssa.201100795
ISI #: 000308942100030
ISSN: 1862-6300
Category: A1
Type: Journal Contribution
Validation: ecoom, 2013
Appears in Collections: Research publications

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