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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/14304

Title: Relation between diabetes, metformin treatment and the occurrence of malignancies in a Belgian primary care setting
Authors: Ngwana, Geraldine
Truyers, Carla
Mathieu, Chantal
Bartholomeeusen, Stefaan
WAMI, Welcome
Buntinx, Frank
Issue Date: 2012
Abstract: Background: Associations between type 2 diabetic patients and a higher risk of developing cancer have been reported worldwide. Recently, a protective effect of metformin has been described. Aim: To examine in the Belgian primary care population the relation between presence of type 2 diabetes with and without metformin treatment and the occurrence of malignancies. Design of study: Retrospective cohort study, based on the Intego database, an ongoing Belgian general practice-based morbidity registry, covering 90 general practitioners and including about 1.5 million patient-years between 1994 and 2008. Method: Cox proportional hazard analysis comparing emergence of malignancy in patients with and without type 2 diabetes, and among patients with diabetes comparing emergence of malignancy in those treated with various antidiabetic drugs. Results: Malignancies occurred more in type 2 diabetic patients compared to non-diabetic controls (HR = 1.84; 95% CI = 1.51-2.24), adjusted for age, gender and weight. Treatment with both metformin and 'other' antidiabetic agents was related to decreased cancer risk (HR = 0.24 and 0.22) compared to diet only in men but not in women. Conclusion: In this Belgian primary care setting, diabetic patients have higher cancer prevalences than non-diabetic patients. Moreover, in diabetic men, not only metformin but also other antidiabetic agents were associated with lower cancer risks. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
Notes: Frank, B (reprint author),ACHG KULeuven, Kapucijnenvoer 33,Blok J,Bus 7001, B-3000 Louvain, Belgium. [Show the Organization-Enhanced name(s)] [Geraldine, Ngwana; Marc, Aerts; Welcome, Wami] Univ Hasselt, Ctr Stat, Hasselt, Belgium. [Carla, Truyers; Stefaan, Bartholomeeusen] Katholieke Univ Leuven, Dept Gen Practice, Louvain, Belgium. [Chantal, Mathieu] Katholieke Univ Leuven, Dept Endocrinol, Louvain, Belgium. [Frank, Buntinx] Maastricht Univ, Caphri Res Sch, Maastricht, Netherlands. frank.buntinx@med.kuleuven.be
URI: http://hdl.handle.net/1942/14304
DOI: 10.1016/j.diabres.2012.02.002
ISI #: 000307823400028
ISSN: 0168-8227
Category: A1
Type: Journal Contribution
Validation: ecoom, 2013
Appears in Collections: Research publications

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