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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/14221

Title: Pathogenic features of CD4(+)CD28(-) T cells in immune disorders
Authors: BROUX, Bieke
Markovic-Plese, Silva
STINISSEN, Piet
HELLINGS, Niels
Issue Date: 2012
Publisher: ELSEVIER SCI LTD
Citation: TRENDS IN MOLECULAR MEDICINE, 18 (8), p. 446-453
Abstract: Aging of the immune system contributes to the increased morbidity and mortality of the elderly population and may occur prematurely in patients with immune disorders. One of the main characteristics of immunosenescence is the expansion of CD4(+)CD28(-) T cells in the blood. These cells are effector memory T cells with cytotoxic capacity, and have been recently described to have pathogenic potential in a variety of immune disorders. Interestingly, CD4(+)CD28(-) T cells have now been found to infiltrate target tissues of patients with multiple sclerosis, rheumatoid arthritis, myopathies, acute coronary syndromes, and other immune-related diseases. In this review, we discuss potential factors and mechanisms that may induce the expansion of these cells, as well as their putative pathogenic mechanisms in immune disorders.
Notes: [Broux, Bieke; Stinissen, Piet; Hellings, Niels] Hasselt Univ, Biomed Res Inst, B-3590 Diepenbeek, Belgium. [Broux, Bieke; Stinissen, Piet; Hellings, Niels] Transnat Univ Limburg, Sch Life Sci, B-3590 Diepenbeek, Belgium. [Markovic-Plese, Silva] Univ N Carolina, Dept Neurol, Chapel Hill, NC 27514 USA. [Markovic-Plese, Silva] Univ N Carolina, Dept Microbiol & Immunol, Chapel Hill, NC 27514 USA. niels.hellings@uhasselt.be
URI: http://hdl.handle.net/1942/14221
DOI: 10.1016/j.molmed.2012.06.003
ISI #: 000307912300003
ISSN: 1471-4914
Category: A1
Type: Journal Contribution
Validation: ecoom, 2013
Appears in Collections: Research publications

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