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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/14192

Title: Cell therapy in neonatal hypoxic ischemic encephalopathy
Authors: De Munter, Stephanie
Advisors: KRAMER, Boris W.
Issue Date: 2012
Publisher: tUL Diepenbeek
Abstract: Perinatal hypoxic-ischemic encephalopathy (HIE) is a major cause of preterm brain injury. In the Western world, there has been a tremendous increase in preterm birth rates over the past 20 years and the incidence of perinatal HIE is estimated at two to six per 1000 live-born infants. Currently, few treatment options are available for preterms suffering from HIE. In this translational research project, we hypothesize that Mesenchymal Stem Cells (MSC) and Granulocyte-Colony Stimulating Factor (G-CSF) therapies can reduce hypoxic-ischemic related synapse loss, neurodegeneration, microglial proliferation and damage to pre-oligodendrocytes in a fetal sheep model, thereby limiting preterm HIE.
Notes: master in de biomedische wetenschappen-klinische moleculaire wetenschappen
URI: http://hdl.handle.net/1942/14192
Category: T2
Type: Theses and Dissertations
Appears in Collections: Master theses

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