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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/14147

Title: Longitudinal data analysis of data on outpatient antibiotic use in Europe
Authors: Bruyndonckx, Robin
Advisors: HENS, Niel
COENEN, Samuel
Issue Date: 2012
Publisher: tUL Diepenbeek
Abstract: Antibiotics are drugs used to treat bacterial infections. The use and misuse of antibiotics has over time lead to resistance of bacteria to several antibiotics. As a start to face this problem trustworthy information related to antibiotics consumption needs to be gathered. In this study the IMS Health data, expressed in both DID and PID and measured from 2000 until 2008, were used to analyze the global trend and seasonal fluctuations in antibiotic consumption. Nonlinear mixed models were constructed assessing both the change of antibiotic consumption over time and the change in seasonal fluctuation. To assess whether both models were in agreement a joint nonlinear mixed model was built containing information on both DID and PID. The change in DDD per package over time was assessed through a linear mixed model.
Notes: Master of Statistics-Biostatistics
URI: http://hdl.handle.net/1942/14147
Category: T2
Type: Theses and Dissertations
Appears in Collections: Master theses

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