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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/13847

Title: Resonantly excited AlN-based microcantilevers for immunosensing
Authors: Oliver, M. J.
Hernando-Garcia, J.
Ababneh, A.
Seidel, H.
Schmid, U.
Andres, J.P.
Pobedinskas, P.
Haenen, K.
Sanchez-Rojas, J. L.
Issue Date: 2012
Publisher: SPRINGER
Abstract: The purpose of this work is to study the performance of resonantly driven microcantilevers excited with a piezoelectric aluminium nitride thin film as a mass sensor for the detection of interactions in the field of immunosensing. Two cantilevers with different width (i.e. 300 and 200 mu m), but constant length and thickness of 300 and 20 mu m were considered. The figures of merit of these structures, such as the mass sensitivity and the limit of mass detection, were determined. According to the results obtained, a cantilever being 300 x 200 mu m(2) in size and a high frequency mode was the best combination to detect antibody/antigen interactions. The previous combination was applied to detect the affinity between rabbit immunoglobulin G (IgG) and the complementary anti-rabbit IgG produced in goat. The binding was registered as a shift of the resonance frequency of the mode under investigation and the correlation between the added mass and the measured shift is analysed.
Notes: [Oliver, M. J.; Hernando-Garcia, J.; Sanchez-Rojas, J. L.] Univ Castilla La Mancha, ETSI Ind, Dept Ingn Elect Elect Automat & Comunicac, E-13071 Ciudad Real, Spain. [Ababneh, A.] Yarmouk Univ, Hijjawi Fac Engn Technol, Dept Elect Engn, Irbid, Jordan. [Seidel, H.] Univ Saarland, Fac Nat Sci & Technol 2, Chair Micromech, D-66123 Saarbrucken, Germany. [Schmid, U.] Vienna Univ Technol, Dept Microsyst Technol, A-1040 Vienna, Austria. [Andres, J. P.] Univ Castilla La Mancha, ETSI Ind, Dept Fis Aplicada, E-13071 Ciudad Real, Spain. [Pobedinskas, P.; Haenen, K.] Hasselt Univ, Inst Mat Res IMO, Wide Band Gap Mat Grp, Diepenbeek, Belgium. [Pobedinskas, P.; Haenen, K.] Hasselt Univ, Div IMOMEC, Diepenbeek, Belgium.
URI: http://hdl.handle.net/1942/13847
DOI: 10.1007/s00542-012-1444-x
ISI #: 000305691500029
ISSN: 0946-7076
Category: A1
Type: Journal Contribution
Validation: ecoom, 2013
Appears in Collections: Research publications

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