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|Title: ||Pharmacokinetics of the Perioperative Use of Cancer Chemotherapy in Peritoneal Surface Malignancy Patients|
|Authors: ||Van der Speeten, K.|
Stuart, O. A.
Sugarbaker, P. H.
|Issue Date: ||2012|
|Publisher: ||HINDAWI PUBLISHING CORPORATION|
|Citation: ||GASTROENTEROLOGY RESEARCH AND PRACTICE, 2012 (Article ID 378064)|
|Abstract: ||Background. The peritoneal surface is an acknowledged locoregional failure site of abdominal malignancies. Previous treatment attempts with medical therapy alone did not result in long-term survival. During the last two decades, new treatment protocols combining cytoreductive surgery with perioperative intraperitoneal and intravenous cancer chemotherapy have demonstrated very encouraging clinical results. This paper aims to clarify the pharmacologic base underlying these treatment regimens. Materials and Methods. A review of the current pharmacologic data regarding these perioperative chemotherapy protocols was undertaken. Conclusions. There is a clear pharmacokinetic and pharmacodynamic rationale for perioperative intraperitoneal and intravenous cancer chemotherapy in peritoneal surface malignancy patients.|
|Notes: ||[Van der Speeten, K.; Govaerts, K.] Oost Limburg Hosp, Dept Surg Oncol, B-3600 Genk, Belgium. [Van der Speeten, K.] Univ Hasselt, Fac Med, Dept Biochem, B-3590 Diepenbeek, Belgium. [Van der Speeten, K.; Stuart, O. A.; Sugarbaker, P. H.] Washington Hosp Ctr, Washington Canc Inst, Washington, DC 20010 USA.|
|ISI #: ||000305653300001|
|Type: ||Journal Contribution|
|Validation: ||ecoom, 2013|
|Appears in Collections: ||Research publications|
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