Document Server@UHasselt >
Research >
Research publications >

Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/13789

Title: Towards water compatible MIPs for sensing in aqueous media
Authors: Horemans, F.
Weustenraed, A.
Spivak, D.
Cleij, T. J.
Issue Date: 2012
Citation: JOURNAL OF MOLECULAR RECOGNITION, 25 (6), p. 344-351
Abstract: When synthesizing molecularly imprinted polymers (MIPs), a few fundamental principles should be kept in mind. There is a strong correlation between porogen polarity, MIP microenvironment polarity and the imprinting effect itself. The combination of these parameters eventually determines the overall binding behavior of a MIP in a given solvent. In addition, it is shown that MIP binding is strongly influenced by the polarity of the rebinding solvent. Because the use of MIPs in biomedical environments is of considerable interest, it is important that these MIPs perform well in aqueous media. In this article, various approaches are explored towards a water compatible MIP for the target molecule l-nicotine. To this end, the imprinting effect together with the MIP matrix polarity is fine-tuned during MIP synthesis. The binding behavior of the resulting MIPs is evaluated by performing batch rebinding experiments that makes it possible to select the most suitable MIP/non-imprinted polymer couple for future application in aqueous environments. One method to achieve improved compatibility with water is referred to as porogen tuning, in which porogens of varying polarities are used. It is demonstrated that, especially when multiple porogens are mixed, this approach can lead to superior performance in aqueous environments. Another method involves the incorporation of polar or non-polar comonomers in the MIP matrix. It is shown that by carefully selecting these monomers, it is also possible to obtain MIPs, which can selectively bind their target in water. Copyright (c) 2012 John Wiley & Sons, Ltd.
Notes: [Cleij, T. J.] Maastricht Univ, Maastricht Sci Programme, NL-6200 MD Maastricht, Netherlands. [Horemans, F.; Weustenraed, A.; Cleij, T. J.] Hasselt Univ, Inst Mat Res, B-3590 Diepenbeek, Belgium. [Spivak, D.] Louisiana State Univ, Dept Chem, Baton Rouge, LA 70803 USA.
URI: http://hdl.handle.net/1942/13789
DOI: 10.1002/jmr.2191
ISI #: 000304468900007
ISSN: 0952-3499
Category: A1
Type: Journal Contribution
Validation: ecoom, 2013
Appears in Collections: Research publications

Files in This Item:

Description SizeFormat
N/A458.38 kBAdobe PDF

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.